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Faculty of Pharmaceutical Sciences

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Researcher ID

Assistant Professor Dr Shaik Ibrahim Khalivulla

Assistant Professor | Department of Pharmaceutical Chemistry

Academic Qualifications

PhD (Chemistry)
M.Sc. (Organic Chemistry)
B.Ed. (Physical Sciences)
Bachelor of Science (Hons) (Physics, Chemistry, Zoology)

Areas of Interest
Bioassay guided fractionation and isolation of the bioactive natural products.
Computer aided drug design and discovery
Design and synthesis of Bio-active natural products and their analogues.
Isolation and characterization of bioactive natural products
Method development for the analysis of herbal medicinal drugs
Ultra-violet, Infrared, Mass, NMR Spectral characterization of the bioactive compounds.
Pharmaceutical analysis of the marketed drugs.
Semi-synthesis of bioactive constituents
Professional Bodies Membership

  1. Member in Malaysian Natural Products Society (MNPS) Dec’ 2017 – Dec’2018
  2. Member in Malaysian Society for Biochemistry and Molecular Biology (MSBMB) since Feb’ 2018
  3. Fellow in Institute for Engineering Research and Publication (IFERP) since Feb’ 2019

Research

Research project

Grants

Collaboration

Status

Design and Synthesis of Andrographolide Derivatives and their in vitro analysis of Acetylcholinesterase (AChE) enzyme inhibition (PI)

Research Excellence & Innovation Grant (REIG), UCSI University, Malaysia

2020-2022, Project Code: REIG-FPS-2020/051

Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University

Ongoing

Investigation on chemical Characterizations of the bioactive extracts of Keladi Candek (Alocasia longiloba Miq.) for wound healing

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme

FRGS/1/2016/WAB07/UMK/02/2

Universiti Malaysia Kelantan, Malaysia

Completed

Development and Validation of HPTLC and FTIR methods for the determination of Alendronate sodium in tablets

Pioneer Scientist Incentive Fund (PSIF)

Proj-In-FPS-010

UCSI University

Completed

Phytochemical Analysis, Preliminary Screening of Anti-cancer Activity and Oral Toxicity Study of Clinacanthus nutans Leaves Extract

CERVIE RGS

Proj-In-FPS-003

UCSI University

Completed

 

Supervision:

PhD students (Current)

  • Aya Yaseen Mahmood Alabdali
  • Shorouq Abdelqader Ahmad Alqazaqi
  • Suzie Haryanti binti Husain

 

Master students (Current)

  • Zhang Yanzhao

Master students (Completed)

  • Sawsan Ibrahim (2016)

 

Undergraduate students (Current)

  • Tan Wei Hsia
  • Gan Min Huei

Undergraduate students (Completed)

  • Tan Ker Ying (2019)

Publications

  1. Gampa M., Padmaja P., Khalivulla S.I., Reddy P.N. Synthesis, antimicrobial and antioxidant activity of 1,2,3-triazole tethered xanthone derivatives, Russ. J. Org. Chem., 2021, Accepted.
  2. Mohammed A., Muniandy R., Abdulhafiz F., Al-Amsyar S.M., Priya Y.K., Khalivulla S.I. Phytochemical analysis and In Vitro antidiabetic potential of Labu Kayu (Crescentia cujete L.) fruit extracts, AIP Conf. Proc., 2021, Accepted.
  3. Alabdali A.Y.M., Chinnappan S., Rajagopal M., Khalivulla S.I., Rahman S.A.K.M.E.H. Pharmacological activities of curcumin: An update, Res. J. Pharm. Technol., 2021, 14(12) Accepted.
  4. Alabdali A.Y.M., Chinnappan S., Razik B.M.A., Mogana R., Khalivulla S.I., Rahman H., Samein L.H.  “Impact of COVID-19 on multiple body organ failure: A Review”, Int. J. Appl. Pharm. 2021, 13, 54-59.
  5. Hussain S.H., Mohammed A., Ch’ng H.Y., Khalivulla S.I. Residual effects of calcium amendments on oil palm growth and soil properties, IOP Conf. Ser.: Earth Environ. Sci. 2021, 756, 012060.
  6. Khalivulla S.I., Mohammed A., Mallikarjuna K. “Novel phytochemical constituents and their potential to manage diabetes”, Curr. Pharm. Des., 2021, 27, 775-788.
  7. Ying T.K., Shukkoor M.S.A., Khalivulla S.I. “In-silico screening of selected flavanones for HMG CoA reductase inhibitory activity”, Curr. Trends Biotechnol. Pharm., 2020, 14, 128-139.
  8. Ferid A., Arifullah M., Khalivulla S.I., Mallikarjuna K., Razab M.K.A.A. Plant cell and callus cultures as an alternative source of bioactive compounds with therapeutic potential against coronavirus disease (COVID-19), IOP Conf. Ser.: Earth Environ. Sci. 2020, 596, 012099.
  9. Khalivulla S.I., Mohammed A., Sirajudeen K.N.S., Shaik M.I., Ye W., Korivi M. “Novel Phytochemical Constituents and Anticancer activities of the genus, Typhonium”. Curr. Drug Metab., 2019, 20, 946-957.
  10. Hamzah N.H.C., Mohammed A., Sirajudeen K.N.S., Asari M.A., Hamzah Z., Khalivulla S.I. “Keladi candik (Alocasia longiloba Miq.) petiole extracts promote wound healing in a full thickness excision wound model in rats”. Asian Pac. J. Trop. Biomed., 2019, 9, 140-149.
  11. Quah S.Y., Chin J.H., Akowuah G.A., Khalivulla S.I., Yeong S.W., Sabu M.C., Quah S.Y., Chin J.H. “Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans”. Drug Metab. Pers. Ther., 2017, 32, 59-65.
  12. Saoud A., Akowuah G.A., Fatokun O., Mariam A., Khalivulla S.I. “Determination of acarbose in tablets by attenuated total reflectance Fourier transform infrared spectroscopy”. Arch. Ind. Biotechnol., 2017, 1, 20-26.
  13. Ibrahim S., Khalivulla S.I., Akowuah G.A. “Effect of Manganese Ions (Mn2+) on Ninhydrin Colour Development by Alendronate for the Spectrophotometric Determination of Alendronate Sodium in Tablets”. Der Pharma Chemica, 2017, 9, 141-147.
  14. Ibrahim S., Khalivulla S.I., Akowuah G.A. “Determination of Alendronate sodium in tablets by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy”. Current Bioactive Compounds. 2017, 13, 71-77.
  15. Saheb S.B., Krishna N., Khaliuvlla S.I., Mallikarjuna K. “Phytochemical screening and antimicrobial activity of leaf and bark ethanol extracts of marine and terrestrial plants of Xylocarpus species”. World J. Pharm. Res., 2016, 5, 1518-1527.
  16. Chin J.H., Akowuah G.A., Sabu M.C., Khaliuvlla S.I. “Sub-Acute (28 Days) toxicity study of methanol leaves extract of Clinacanthus nutans in rats”. Int. J. Pharm., 2014, 4, 61-69.
  17. Kala S.C., Vijayalakshmi M., Khaliuvlla S.I., Mallikarjuna K. “Phytochemical and Antimicrobial Analysis of Callus Extracts of Biophytum sensitivum (Linn) DC”. British Microbiol. Res. J., 2014, 4, 869-884.
  18. Ming-Tatt L., Khaliuvlla S.I., Akhtar M.N., Lajis N., Perimal E.K., Akira A., Israf D.A., Sulaiman M.R. “Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP”. Pharmacol. Biochem. Behavior, 2013, 114-115, 58-63.

Conferences

  1. Cytotoxicity study of Clinacanthus nutans on Human Liver Cancer Cell (Hep-G2). 8th International Traditional and Complementary Medicine, 30th October – 2nd November 2014, Sunway Pyramid Convention Centre, Malaysia
  2. Sub-Acute (28 Days) toxicity study of methanol leaves extract of Clinacanthus nutans in rats. 27th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting, September 6-8, 2013, MS Garden Hotel, Kuantan, Pahang, Malaysia
  3. SRJ23, a promising new anti-prostate cancer agent. Pemaran Reka Cipta, Penyelidikan dan Inovasi 2009 (PRPI’09), July 28-30, 2009, Page 51. Universiti Putra Malaysia, Malaysia

Journal Reviewers

  • J Enzyme Inhib Med Chem; Toxicology and Industrial Health
  • Saudi Pharmaceutical Journal (ELSEVIER)
  • Vietnam Journal of Chemistry (WILEY)
  • Medicinal Chemistry Research (SPRINGER)

Awards and Recognitions

  1. SRJ23, a promising new anti-prostate cancer agent. Pemaran Reka Cipta, Penyelidikan dan Inovasi 2009 (PRPI’09), 28th July, 2009. Universiti Putra Malaysia, Malaysia (GOLD MEDAL).
  2. TEA–4G, Herbal remedy for Gout, Malaysia Technology Expo – 2020, 20-22nd February 2020 Putra World Trade Centre, Kuala Lumpur, Malaysia (GOLD AWARD).
  3. TEA–4G, 31st International Invention Innovation & Technology Exhibition, Malaysia – 2020, 20,21st November 2020, Virtual (GOLD MEDAL).

 

Others 

External examiner (dissertation)

  • External advisor, “Pharmacological screening and toxicity studies of pharmaceuticals” for AMIPRO LAB (Collaboration with IPHARM-NIBN), Penang, Malaysia, since May 2018.
  • PhD in Natural Science, Acharya Nagarjuna University, India, “A Study on the production and chemical characterization on bioactive compounds from Arthrobacter kerguelensis VL-RK_09”.
  • PhD in Natural Science, Acharya Nagarjuna University, India, “Bioactive metabolites from a rare Actinobacterium nocardiopsis Sp. Vjsy-1 isolated from mangrove sediments”.