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Associate Professor Dr. Cheah Shiau Chuen

ASSOCIATE PROFESSOR DR. CHEAH SHIAU CHUEN

Associate Professor Dr. Cheah Shiau Chuen

Associate Professor of Biochemistry

Head of Praxis, Industry and Community Engagement
 

Academic Qualifications

PhD Biochemistry
BSc (Hons) Biochemistry

Areas of Interest
Cancer Biology
Tumor Microenvironment
Angiogenesis
Natural product and drug discovery
Drug screening & Bioassays
Professional Bodies

  1. Member of European Association of Cancer Research (EACR)
  2. Member of American Society for Biochemistry and Molecular Biology (ASBMB)
  3. Member of Malaysian Society for Biochemistry and Molecular Biology (MSBMB)
  4. Member of Malaysian Society of Natural Products (MSNP)

Research

Research Grants

  1. FISH detection on Gene Rearrangement of Malaysian (FRGS)
  2. Screening and investigate Pro- & Anti-Angiogenesis potential In-Vitro effect on Malaysian plants (FRGS)
  3. Notch and Wnt Specific Phytochemicals Inhibitors of Cancer Stem Cells (CSC)

 

Current Research Project 

  1. Notch and Wnt Specific Inhibitors of Cancer Stem Cells (CSC)
  2. NPC Tumour Microenvironment

Publications

Year 2021

  1. Win Sen Heng, Shiau-Chuen Cheah. (2021) Identification of Phytochemical-Based -Catenin Nuclear Localization Inhibitor in LSCLC: Differential Targeting Population from Member of Isothiocyanates.
  2. Win Sen Heng, Milind Pore, Coby Meijer, T. Jeroen N. Hiltermann, Shiau-Chuen Cheah, Reinoud Gosens, Frank A.E. Kruyt. (2021) A Unique Small Cell Lung Carcinoma Disease Progression Model shows Progressive Accumulation of Cancer Stem Cell Properties and CD44 as a Potential Diagnostic Marker.
  3. Yi Na Tee, Palanirajan Vijayaraj Kumar*, Marwan Abdelmahmoud Abdelkarim Maki, Manogaran Elumalai, Shiek Abdul Kadhar Mohamed Ebrahim Habibur Rahman, Shiau-Chuen Cheah. (2021) Mucoadhesive Low Molecular Chitosan Complexes to Protect rHuKGF from Proteolysis: In-vitro Characterization and FHs 74 Int Cell Proliferation Studies

Year 2018

  1. Chia-Wei Phan, Joon-Keong Wang, Elson Yi-Yong Tan, Yee-Shin Tan, Jaya Seelan Sathiya Seelan, Shiau-Chuen Cheah & Sabaratnam Vikineswary. (2018) Giant oyster mushroom, Pleurotus giganteus (Agaricomycetes): current status of the cultivation methods, chemical composition, biological, and health-promoting properties. Food Reviews International
  2. Lee Siew­ Keah, Margaret Flori Vasthian Patrick, Chia Kam Weng, Lee Chew Kek, Lee Bang Rom, Lim Chai Leng, Tan Geok Puan, Cheah Shiau Chuen, Tan Chung Keat. (2018). Evaluation of Histopathological Changes in Idiopathic Cutaneous Hyperchromia at the Orbital Region. Surgical and Cosmetic Dermatology
  3. Palanirajan Vijayaraj Kumar, Marwan Abdelmahmoud Abdelkarim Maki, Yeong Siew Wei, Lee Ming Tatt, Manogaran Elumala. (2018) Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles. Curr Clin Pharmacol. 

 

Year 2017

  1. Phan Chia Wei, Wang Joon Keong, Murali Naidu, Cheah Shiau Chuen, Pamela David, Vikineswary Sabaratnam (2017) A review on the nucleic acid constituents in mushrooms: nucleobases, nucleosides, and nucleotides. Critical Reviews in Biotechnology 
  2. Shayma A. Shaker, Hamid Khaledi, Shiau-Chuen Cheah, Hapipah Mohd Ali. (2017). Arabian Journal of Chemistry. (2017) New Mn(II), Ni(II), Cd(II), Pb(II) complexes with 2-methylbenzimidazole and other ligands, synthesis, spectroscopic characterization, crystal structure, magnetic susceptibility and biological activity studies

 

Year 2013

  1. Syam Mohan, Siddig Ibrahim Abdelwahab, Shiau-Chuen Cheah, Mohd Aspollah Sukari, Suvitha Syam, Mohd. Rais Mustafa and Noorasyikin Shamsuddin. 2013. Apoptosis effect of Girinimbine isolated from Murraya koenigii on lung cancer cells in vitro. Evidence-Based Complementary and Alternative Medicine (eCAM). (ISI-Cited Publication, Tier 1; Impact Factor: 4.77).
  2. Masoumeh Hosseinzadeh, A. Hamid A. Hadi, Jamaludin Mohamad, Mohammad A. Khalilzadeh, Shiau-Chuen Cheah & Mehran Fadaeinasab. 2013. Flavonoids and Linderone from Lindera oxyphylla and their Bioactivities. Combinatorial Chemistry & High Throughput Screening. 16(2): 160-166. (ISICited Publication, Tier 2; Impact Factor 1.903)
  3. Shiau-Chuen Cheah, Siew-Li Lai, Sui-Ting Lee, and Mohd. Rais Mustafa. 2013. Panduratin A, a Possible Inhibitor in Metastasize A549 Cells Through Inhibition of NF-Kappa B Translocation and Chemoinvasion. Molecules 18(8), 8764-8778 (ISI-Cited Publication, Tier 2; Impact Factor: 2.428)
  4. Soon Huat Tiong, Chung Yeng Looi, Hazrina Hazni, Aditya Arya, Mohammadjavad Paydar, Won Fen Wong, Shiau-Chuen Cheah, Mohd Rais Mustafa, Khalijah Awang. 2013. Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus. Molecules 18(8): 9770-9784 (ISI-Cited Publication, Tier 2; Impact Factor: 2.428)
  5. Putri Narrima Mohd Fauzi, Cheah Shiau-Chuen, David Ross Appleton, Wong Pooi Fong, Mohd Rais Mustafa, Mustafa Ali Mohd and A. Hamid A. Hadi. 2013. An Investigation on Bioactive Constituents from Persea declinata (bl.) Kosterm. The Open Conference Proceedings Journal. Pp 38-42

 

Year 2012

  1. Nor Hadiani Ismail, Ahmad Nazif Aziza, Norizan Ahmata, Cheah Shiau-Chuen and Khalijah Awang. 2012. Chemical Constituents from Cytotoxic Extract of Croton laevifolius. Current Medicinal Chem. P.g 153 (ISI-Cited Publication, Tier 1, Impact Factor: 4.859).
  2. Siddig Ibrahim Abdelwahab, Loiy Elsir Ahmed Hassan, Amin MS Abdul Majid, Sakina M. Ahmed Yagi, Syam Mohan, Manal Mohamed Elhassan Taha, Syahida Ahmad, Cheah Shiau-Chuen, Putri Narrima, Mohd Mustafa Rais, Suvitha Syam, Bushra Abdulkarim Moharam and A. Hamid A. Hadi. 2012. Cucurbitacin L 2-O- glucoside demonstrates apoptogenesis in colon adenocarcinoma cells (HT-29): involvement of reactive oxygen and nitrogen species regulation. Evidence-Based Complementary and Alternative Medicine (eCAM). Volume 2012, Article ID 49013, doi:10.1155/2012/490136 (ISI-Cited Publication, Tier 1; Impact Factor: 4.77).
  3. Aditya Arya, Mouna Achoui, Shiau-Chuen Cheah, Siddig Ibrahim Abdelwahab, Putri Narrima, Syam Mohan, Mohd Rais Mustafa and Mustafa Ali Mohd. 2012. Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. Evidence Based Complementary and Alternative Medicine (eCAM), vol. 2012, Article ID 627256, (ISI-Cited Publication, Tier 1; Impact Factor: 4.77).
  4. Siew-Li Lai, Shiau-Chuen Cheah, Pooi-Fong Wong, Suzita Binti Mohd Noor and Mohd Rais Mustafa. 2012. In vitro and In vivo Anti-angiogenic Actvities of Panduratin A. PlosOne http://dx.plos.org/10.1371/journal.pone.0038103 (ISI-Cited Publication, Tier 1; Impact Factor: 4.40)
  5. Aditya Arya, Chung Yeng Looi, Shiau-Chuen Cheah, Mohd Rais Mustafa and Mustafa Ali Mohd. 2012. Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats. Journal of Ethnopharmacology. http://0- www.sciencedirect.com.precise.petronas.com.my/science/article /pii/S0378874112005399 (ISI-Cited Publication, Tier 1; Impact Factor: 3.728)
  6. Syam Mohan, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Suvitha Syam, Koh Sue May, Nabil Saad Mohammed Harmal, Noor Shafifiyaz, A. Hamid A. Hadi, Najihah Mohd Hashim, Mawardi Rahmani, Manal Mohamed Elhassan Taha, Shiau-Chuen Cheah, Asdren Zajmi. 2012. Involvement of NF-kB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine http://www.sciencedirect.com/science/article/pii/S0944711312 001900 (ISI-Cited Publication, Tier 1; Impact Factor: 3.268)
  7. Aditya Arya, Shiau-Chuen Cheah, Chung-Yeng Looi, Hairin Taha, Mohd. Rais Mustafa and Mustafa Ali Mohd. 2012. The methanolic fraction of Centratherum anthelminticum seed down regulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats. Food and Chemical Toxicology http://dx.doi.org/10.1016/j.fct.2012.08.012 (ISI-Cited Publication, Tier 1; Impact Factor: 3.078).
  8. Abbas Mollataghi, A.hamid A.hadi & Shiau-Chuen, Cheah. 2012. (-)-Kunstleramide, a New Antioxidant and Cytotoxic Dienamide from the bark of Beilschmiedia kunstleri Gamble. Molecules 17(4), 4197-4208 (ISI-Cited Publication, Tier 2; Impact Factor: 2.386)
  9. Kong Wai Tan, Hoi Ling Seng, Fei Shen Lim, Shiau-Chuen Cheah, Chew Hee Ng, Mohd. Rais Mustafa, Seik Weng Ng, Mohd. Jamil Maah. 2012. Towards a selective cytotoxic agent for prostate cancer: Interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with Topoisomerase I. Polyhedron http://linkinghub.elsevier.com/retrieve/pii/S0277538712 001404 (ISI-cited Publication, Tier 2; Impact Factor: 2.118)
  10. Shayma A. Shaker, Hamid Khaledi, Shiau-Chuen Cheah, Hapipah Mohd Ali. 2012. New Mn(II), Ni(II), Cd(II), Pb(II) complexes with 2-methylbenzimidazole and other ligands, synthesis, spectroscopic characterization, crystal structure, magnetic susceptibility and biological activity studies. Arabian Journal of Chemistry. http://dx.doi.org/10.1016/j.arabjc.2012.06.013 (ISI Cited Publication, Tier 2; Impact Factor: 1.367)
  11. Isa NM, Abdelwahab SI, Mohan S, Abdul AB, Sukari MA, Taha MM, Syam S, Narrima P, Cheah SC, Ahmad S, Mustafa MR. 2012. In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot). Braz J Med Biol Res. http://dx.doi.org/10.1590/S0100-879X2012007500022 (ISICited Publication, Tier 3; Impact Factor: 1.129).
  12. Mariod, A.A., Abdelwahab, S.I., Elkheir, S., Ahmed, Y. M., Fauzi, P. N. M., Cheah S.C. 2012. Antioxidant Activity Of Different Parts From Annona Squamosa, And Catunaregam Nilotica Methanolic Extract. ACTA Scientiarum Polonorum Technologia Alimentaria. 11(3) 2012, 249-257 (Scopus-cited publication)

 

Year 2011

  1. Sui-Ting Lee; Pooi-Fong Wong; Shiau-Chuen Cheah; Mohd Rais Mustafa. 2011. Alpha-Tomatine Induces Apoptosis and Inhibits Nuclear Factor-Kappa B Activation on Human Prostatic Adenocarcinoma PC-3 Cell. PLoS ONE 6(4): e18195 (ISI-Cited Publication, Tier 1; Impact Factor: 4.40).
  2. Shiau-Chuen Cheah, David R. Appleton, Sui-Ting Lee, May-Lynn Lam, A. Hamid A. Hadi & Mohd. Rais Mustafa. 2011. Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF-KappaB Translocation. Molecules 16, 2583-2598 (ISI-Cited Publication, Tier 2; Impact Factor: 2.386).
  3. Siddig Ibrahim Abdelwahab, Loiy Elsir Ahmed Hassan, Hasnah Mohd Sirat, Sakina M. Ahmed Yagi, Waleed S. Koko, Syam Mohan, Manal Mohamed Elhassan Taha, Syahida Ahmad, Cheah Shiau-Chuen, Putri Narrima, Mohd Mustafa Rais. 2011. AntiInflammatory activities of cucurbitacin E: role of reactive nitrogen species and cyclooxygenase enzymes inhibition. Fitoterapia 82(8): 1190-1197 (ISI-Cited Publication, Tier 2; Impact Factor: 2.00)

 

Year 2010

  1. David R. Appleton, Cheah Shiau-Chuen, Michael V. Berridge, Victoria L. Webb, Brent R. Copp. 2010. Rossinones A (I) and B (II), Biologically Active Meroterpenoids from the Antarctic Ascidian, Aplidium species. ChemInform Abstract: Volume 41(17). Article first published online: 1 APR 2010, DOI: 10.1002/chin.201017190 (ISI-Cited Publication) 

 

Year 2009

  1. David R. Appleton, Cheah Shiau-Chuen, Michael V. Berridge, Victoria L. Webb and Brent R. Copp. 2009. Rossinones A and B, Biologically Active Meroterpenoids from the Antarctic Ascidian, Aplidium species. J. Org. Chem. 74 (23), 9195–9198. (ISI-Cited Publication, Tier 1; Impact Factor: 4.450) 

Conferences

  1. The Effects Of Uridine On Amyloid Beta (Aβ)-Treated Human Neuroblastoma (Sh-Sy5y) And Mouse Neuroblastoma (N2a) Cells. Joon-Keong Wang, Shiau-Chuen Cheah, Chia-Wei Phan, Vikineswary Sabaratnam. International Congress of the Malaysian Society for Microbiology (ICMSM) 2017. Kuala Lumpur 2017. Malaysian Society for Microbiology
  2. Chelrythrine chloride inhibits Wnt/β-catenin pathway dose-independently on Wnt dependent lung cancer cell line NCI-H1703. Cheah Shiau-Chuen, Heng Win-Sen, Peh Suat-Cheng. Defence is the best attack: Immuno-Oncology Breakthrough. Barcelona, Spain: 09-11 Oct 2017. European Association Cancer Research
  3. FISH identifies MYC, BCL2 and BCL6 gene rearrangement in B-cell Non-Hodgkin Lymphoma among Malaysian. Cheah Shiau-Chuen, Dayang Sharyati Datu Abdul Salam, Ei Ei Thit, Teoh Siew Hoon, Tan Soo Yong, Peh Suat Cheng. European Human Genetics Conference - ESHG 2017. Copenhagen, Denmark from May 27-30, 2017. European Human Genetics.
  4. Impact of air pollution on food intake among indoor and outdoor workers: a comparison. Thavin KMS, Tan ESS, Cheah SC, Lim HS, Seghayat MS, Normina AB, ­Tan CK. 1st Southeast Asia Public Health Nutrition Conference. Kuala Lumpur, 14th to 17th May 2017. SEA-PHN
  5. Application of Fluorescence in situ Hybridization (FISH) in the Diagnosis of Malaysian Lymphomas. Dayang Sharyati Datu Abdul Salam, Ei Ei Thit, Teoh Siew Hoon, Tan Soo Yong, Peh Suat Cheng, Cheah Shiau-Chuen. 3 PAN-ASIAN BIOMEDICAL SCIENCE CONFERENCE. 7 - 8 December 2016 at the Premiera Hotel Kuala Lumpur, Malaysia. UKM Medical Molecular Biology Institute
  6. Targeted Treatment Towards Periorbital Hyperpigmentation Reduction Through Depigmentation. Cheah Shiau-Chuen, Chia Kam Weng, Tan Chung Keat. The 14th Symposium of Malaysian Society of Applied Biology. 29th – 31st May 2016, Malacca, Malaysia. Malaysian Society of Applied Biology (MSAB)
  7. Identification of Wnt inhibitors on Lung Cancer Stem Cell. Heng Win Sen, Peh Suat Cheng, Cheah Shiau-Chuen. 6th Regional Conference on Molecular Medicine in conjunction with 2nd National Conference for Cancer Research. 23rd - 25th October 2015. UKM Medical Molecular Biology Institute

Networks and Collaborations on Research

  1. University Medical Center of Groningen, Netherlands 
  2. Duke-NUS Graduate Medical School; Singapore General Hospital; Singhealth Tissue Repository, Institute of Cell and Molecular Biology (IMCB) 
  3. Industry collaboration - Sime Darby Technology Centre

Contributions to Society

  1. European Association of Cancer Research (EACR)
  2. American Society for Biochemistry and Molecular Biology (ASBMB)
  3. Malaysian Society of Natural Products (MSNP)
  4. Malaysian Society for Biochemistry and Molecular Biology (MSBMB)