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Associate Professor Dr. Gabriel Akyirem Akowuah

Associate Professor of Pharmaceutical Chemistry (Pharmaceutical Analysis)

Head of Department, Pharmaceutical Chemistry & Head of Programme, Bachelor of Formulation Science (Hons) | Department of Pharmaceutical Chemistry
 

Academic Qualifications

PhD (Pharmaceutical Chemistry)
M.Sc. (Pharmaceutical Chemistry)
Bachelor of Science (Hons)
Dip.Ed

Areas of Interest
Pharmacokinetic
Interactions of Herbal Medicinal Products
Pharmacokinetics of bioactive compounds in botanical drugs and plant extracts
Analytical and bioanalytical method development
Drug interaction studies
Research

Current research project (PI/Co-PI)

Grants

Collaboration

Status

Standardisation and Mechanism of Action of Polyherbal Formulation MM-24 for Cutaneous Wound Healing (Co-PI)

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme (FRGS, 2021)

UCSI University

On-going

Pharmacokinetic Interactions of Standardized Extract of Vernonia amydgdalina Del. leaf with metformin/glibenclamide oral Fixed-Dose Combination Therapy for type 2 diabetes mellitus (PI)

Pioneer Scientist Incentive Fund (PSIF)

Proj-2019-In-FPS-025

MAHSA University Universiti Sains Malaysia

On-going

Standardization and the mechanism of action of polyherbal formulation MM-15 for primary dysmenorrhea (Co-PI)

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme

FRGS/1/ 2019WAB07/UCSI/02/1)

 

On-going

Investigating the mechanism of signal transduction pathways of vasorelaxant effect of Limonoids-rich fraction of Swietenia maacrophylla seed and its biomarkers (Co-PI)

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme FRGS/1/2019/STG05/USM/02/10)

Universiti Sains Malaysia

Monash University Malaysia

On-going

Development and validation of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) Methods for the analysis of selected aminoglycosides antibiotics (AGAs) in API and different pharmaceutical dosage forms (Co-PI)

Pioneer Scientist Incentive Fund (PSIF)

Proj-2019-In-FPS-016

 

On-going

Characterisation and potential wound healing activity from partial purified fraction E of DCM leaf extract of Labisia pumila in type1 and type 2 diabetic rats. (Co-PI)

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme

FRGS/2/2013/SG05/ UCSI/02/01

UCSI University

Completed

Purification and identification of potent antioxidative components of tropical fruits peel and their oxidative stabilization effect in cooking oil. (Co-PI)

UCSI UNIV Research Grant Scheme

Proj-In- FAS-006

UCSI University

Completed

 

Supervision:

PhD students (Current)

  • Bassel Al Sabbagh

PhD students (Completed)

  • Nil

 

Master students (Current)

  • Ms. Udyanee Jayaweera

Master students (Completed)

  • Ms. Yau Xin Yi (2020)
  • Mayasah Al-Nema (2018)
  • Bassel Al Sabbagh (2017)
  • Ming Xing (2016)
  • Bassel Al Sabbagh (2016)
  • Ali Saoud (2015)
  • Sawsan Ibrahim (2015)
  • Quah Suk Yen (2015)
  • Foo Rui Ching (2015)
  • Choong Wai Seng (2014)

Undergraduate students (Current)

  • Chow Jie Chen (2021)

Undergraduate students (Completed)

  • Yau Xin Yi (2017)
  • Por Choo Shiuan (2016)
  • Vun Vui Kit (2011)
  • Cheong Wei Kit (2012)
  • Ho Shing Yang (2012)
  • Tiew Wah Peng (2012)
  • Ping Xiu Wen (2012)

Publications

  1. Chin J.H., Akowuah, G.A., Mohamed Salem Abdul Shukkor 2, Anupam Biswas (2021). Modulation of rat hepatic CYP3A4 activity by Brassica oleracea, Hibiscus rosa sinensis, and Tradescantia zebrina. Biointerface Research in Applied Chemistry, 11 (1), 7453 – 7459.   Doi:  https://doi.org/10.33263/BRIAC111.74537459
  2. Akowuah, G.A., Chin J.H., Yeong S.W., Quah, S.Y., Ahmad, M. (2020). In-Vitro CYP3A4, CYP2E1 and UGT activity in human liver microsomes by Strobilanthes crispus leaf extracts. The Natural Product Journal. DOI: 10.2174/2210315509666190304124328
  3. Yau Xin Yi, Anand Gaurav, Akowuah, G.A. (2020). “Docking Studies of Curcumin and Analogues with Various Phosphodiesterase 4 Subtypes”, Current Drug Discovery Technologies, 17 (2): 248-260 https://doi.org/10.2174/1570163815666181017091655
  4. Akowuah, G.A., Chin J.H., Yeong S.W., Quah, S.Y., Ahmad, M. (2019). In-Vitro UDP-Gluuronosyltransferase and Cytochrom P450 enzymes activities of Clinacanthus nutans leaf juice and aqueous extract. Pharmacognosy Magazine, 15(65), 532-537.
  5. Por, C.S., Akowuah, G.A., Gaurav, A. (2018). Quantitative structure-activity relationship modeling of s-triazines and 2-arylpyrimidines as selective PDE4B inhibitors. Thai Journal of Pharmaceutical Sciences, 42(2), 69-83.
  6. Akowuah, G.A., Chin J.H., Yeong S.W., Quah, S.Y., Ahmad, M. (2019). In-Vitro UDP-Gluuronosyltransferase and Cytochrom P450 enzymes activities of Clinacanthus nutans leaf juice and aqueous extract. Pharmacognosy Magazine, 15(65), 532-537.
  7. Yau Xin Yi, Anand Gaurav, Akowuah, G.A. (2018). “Docking Studies of Curcumin and Analogues with Various Phosphodiesterase 4 Subtypes”, Current Drug Discovery
  8. Al-Nema M, Gaurav A, Akowuah A.G (2018). Discovery of Natural Product Inhibitors of Phosphodiesterase 10A as Novel Therapeutic Drug for Schizophrenia Using a Multistep Virtual Screening. Journal of Computational Biology and Chemistry, 77: 52-63. Doi: https://doi.org/10.1016/j.compbiolchem.2018.09.001
  9. Quah, S.Y., Chin, J.H., Akowuah, A.G., Shaik I. K, Yeong, S.W., Chacko Sabu, M. C. (2017). Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans. Drug Metabolism Personalized Therapy, 32 (1): 59-66. Doi: https://doi.org/10.1515/dmpt-2016-0034
  10. Xing, M., Akowuah, A.G., Gautam, V., Gaurav. A. (2016). Structure-based design of selective phosphodiesterase 4B inhibitors based on ginger phenolic compounds. Journal of Biomolecular Structure and Dynamics. 35 (13):  2910-2924  Doi: 10.1080/07391102.2016.1234417
  11. Sawsan, I., Khalivula, S.I., Akowuah, A.G. (2016). Determination of Alendronate sodium in tablets by attenuated total reflectance Fourier transform infrared spectroscopy. Current Bioactive Compounds. 13(1): 71-77. Doi: 10.2174/1573407212999160506112738
  12. Wei, S.K., Priya, M., Chin, J.H., Mariam, A., Akowuah A.G., (2016). Antimicrobial and antiradical activities of Corylus cornuta (marsh., betulacea) kernel extracts.  Oriental Pharmacy and Experimental Medicine, 16 (1),45-51; Doi: 10.1007/s13596-015-0212-8
  13. Akowuah, A.G.,     May,     L.     L.Y.,     Chin     J.      H.      (2015).  Toxicological evaluation of Vernonia amygdalina methanol leave extract in rats. Oriental Pharmacy and Experimental Medicine, 15 (4), 365-369.  Doi: 10.1007/s13596-015-0194-6

 

Conferences

  1. Acute and sub-acute toxicity study of Vernonia amygdalina methanol leave extracts in rats. September 2013, Pahang, Malaysia, Scientific Meeting of Malaysian Society of Pharmacology and Physiology.
  2. 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology, Pahang, Malaysia, 6 th September, 2013. Sub-acute (28 days) Toxicity study of methanol leaves extract of Clinacanthus nutans in rats.
  3. Malaysian Pharmaceutical Society Scientific Conference, Kuala Lumpur, October, 2012). Antibacterial Activity of methanolic extract of Clinacanthus Nutans leaf.
  4. Malaysian Pharmaceutical Society Scientific Conference, Kuala Lumpur, 21st-23rd October, 2011. Klebsiella pneumoniae and Candida albicans using disk diffusion method.
  5. Commonwealth Pharmaceutical Association Conference and Malaysian Pharmaceutical Society Scientific Conference, Kuala Lumpur, August 1st - 5 thAugust, 2007. Radical scavenging activity from methanolic extract of Limonia acidissima.
  6. Anti Tumour from Orthosiphon stamineus Benth; Extracts, standardized to betulinic acid. May 19-21, 2005. Putra World Trade Centre, Kuala Lumpur, 16th International, Invention, Innovation, Industrial Design & Technology Exhibition.
  7. Analysis by high-performance liquid chromatography (gradient system) on sinensetin, 3’-hydroxy-5,6,7,4’-tetramethoxyflavone and eupatorin from localities and batches in spray dried Misai kuching extract. Seminar on Medicinal and Aromatic Plants: Current Trends and Perspectives;July 20-21, 2004, Forest Research Institute Malaysia, Kepong.
  8. International Seminar on Natural Products, 13-16 October, 2003, Kuala Lumpur, “The effect of different solvent extraction systems on polyphenols in Orthosiphon stamineus Leaf.”
  9. Malaysian Pharmaceutical Society Scientific Conference, Penang, 31st October – 2 nd November 2002, Penang, “Spectrophotometry (UV) and HPLCdetermination of rosmarinic acid.”

Editorial Board Membership

  1. The Natural Product
  2. Journal   of   Diabetes Mellitus and Metabolic Syndrome
  3. Journal of Medicinal Chemistry and Toxicology

Journal Reviewers

  • Journal of Pharmaceutical, Chemical and Biological Sciences
  • Archives of Industrial Biotechnology
  • SOJ Chromatographic Science
  • The Natural Product

Community Engagement

  • Catholic Vacation Programme 1994, Archdioceses of Cape Coast, Ghana
  • Catholic Vacation Programme 1995, Archdioceses of Cape Coast, Ghana

Awards and Recognition

  • Bronze Medal ITEX 2005, Anti Tumour Agents from Orthosiphon stamineus Benth., extracts Standardised to Betulinic Acid.
  • University Sains Malaysia, Anugerah Sanggar Sanjung 2005, Kategori Produk Penyelidikan,

External examiner (dissertation)

  • Doctor of Philosophy Thesis. “Synthesis of Pyran Fused Heterocyclic Compounds and Evaluation of Their Biological Activity” Gandhi Institute of Technology and Management (GITAM) University. (2021)
  • Doctor of Philosophy Thesis. “Studies on in vitro propagation, phytochemistry,pharmacology, phytosociology and genetic diversity of an endangered medicinal plant, Strychnos wallichiana Steud. Ex A. Dc.”  Acharya Nagarjuna University. (2020)
  • Doctor of Philosophy Thesis. “Development of Leuprolide acetate loaded microspheres and Triblock Co-polymer Nanoparticles aimed for Oral Drug Delivery”. Andhra University (2019)