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Associate Professor Dr. Gabriel Akyirem Akowuah

Associate Professor Dr. Gabriel Akyirem Akowuah

Associate Professor of Pharmaceutical Chemistry (Pharmaceutical Analysis)

Head of Department, Pharmaceutical Chemistry & Head of Programme, Bachelor of Formulation Science (Hons) | Department of Pharmaceutical Chemistry
 

Academic Qualifications

PhD (Pharmaceutical Chemistry)
M.Sc. (Pharmaceutical Chemistry)
Bachelor of Science (Hons)

Areas of Interest
Pharmacokinetic
Interactions of Herbal Medicinal Products
Research

Current research project (PI/Co-PI)

Grants

Collaboration

Status

Pharmacokinetic Interactions of Standardized Extract of Vernonia amydgdalina Del. leaf with metformin/glibenclamide oral Fixed-Dose Combination Therapy for type 2 diabetes mellitus (PI)

Pioneer Scientist Incentive Fund (PSIF)

Proj-2019-In-FPS-025

MAHSA University Universiti Sains Malaysia

On-going

Standardization and the mechanism of action of polyherbal formulation MM-15 for primary dysmenorrhea (Co-PI)

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme

FRGS/1/ 2019WAB07/UCSI/02/1)

 

On-going

Investigating the mechanism of signal transduction pathways of vasorelaxant effect of Limonoids-rich fraction of Swietenia maacrophylla seed and its biomarkers (Co-PI)

Ministry of Education Malaysia (MoE) Fundamental Research Grant Scheme FRGS/1/2019/STG05/USM/02/10)

Universiti Sains Malaysia

Monash University Malaysia

On-going

Development and validation of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) Methods for the analysis of selected aminoglycosides antibiotics (AGAs) in API and different pharmaceutical dosage forms (Co-PI)

Pioneer Scientist Incentive Fund (PSIF)

Proj-2019-In-FPS-016

 

On-going

 

Supervision:

PhD students (Current)

  • Bassel Al Sabbagh

 

Master students (Completed)

  • Mayasah Al-Nema (2018)
  • Ming Xing (2016)
  • Bassel Al Sabbagh (2016)
  • Ali Saoud (2015)
  • Sawsan Ibrahim (2015)
  • Quah Suk Yen (2015)
  • Foo Rui Ching (2015)
  • Choong Wai Seng (2014)

Publications

  1. Akowuah, G.A., Chin J.H., Yeong S.W., Quah, S.Y., Ahmad, M. (2020). In-Vitro CYP3A4, CYP2E1 and UGT activity in human liver microsomes by Strobilanthes crispus leaf extracts. The Natural Product Journal. DOI: 10.2174/2210315509666190304124328
  2. Akowuah, G.A., Chin J.H., Yeong S.W., Quah, S.Y., Ahmad, M. (2019). In-Vitro UDP-Gluuronosyltransferase and Cytochrom P450 enzymes activities of Clinacanthus nutans leaf juice and aqueous extract. Pharmacognosy Magazine, 15(65), 532-537.
  3. Por, C.S., Akowuah, G.A., Gaurav, A. (2018). Quantitative structure-activity relationship modeling of s-triazines and 2-arylpyrimidines as selective PDE4B inhibitors. Thai Journal of Pharmaceutical Sciences, 42(2), 69-83.
  4. Akowuah, G.A., Chin J.H., Yeong S.W., Quah, S.Y., Ahmad, M. (2019). In-Vitro UDP-Gluuronosyltransferase and Cytochrom P450 enzymes activities of Clinacanthus nutans leaf juice and aqueous extract. Pharmacognosy Magazine, 15(65), 532-537.
  5. Yau Xin Yi, Anand Gaurav, Akowuah, G.A. (2018). “Docking Studies of Curcumin and Analogues with Various Phosphodiesterase 4 Subtypes”, Current Drug Discovery
  6. Al-Nema M, Gaurav A, Akowuah A.G (2018). Discovery of Natural Product Inhibitors of Phosphodiesterase 10A as Novel Therapeutic Drug for Schizophrenia Using a Multistep Virtual Screening. Journal of Computational Biology and Chemistry, 77: 52-63. Doi: https://doi.org/10.1016/j.compbiolchem.2018.09.001
  7. Quah, S.Y., Chin, J.H., Akowuah, A.G., Shaik I. K, Yeong, S.W., Chacko Sabu, M. C. (2017). Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans. Drug Metabolism Personalized Therapy, 32 (1): 59-66. Doi: https://doi.org/10.1515/dmpt-2016-0034
  8. Xing, M., Akowuah, A.G., Gautam, V., Gaurav. A. (2016). Structure-based design of selective phosphodiesterase 4B inhibitors based on ginger phenolic compounds. Journal of Biomolecular Structure and Dynamics. 35 (13):  2910-2924  Doi: 10.1080/07391102.2016.1234417
  9. Sawsan, I., Khalivula, S.I., Akowuah, A.G. (2016). Determination of Alendronate sodium in tablets by attenuated total reflectance Fourier transform infrared spectroscopy. Current Bioactive Compounds. 13(1): 71-77. Doi: 10.2174/1573407212999160506112738
  10. Wei, S.K., Priya, M., Chin, J.H., Mariam, A., Akowuah A.G., (2016). Antimicrobial and antiradical activities of Corylus cornuta (marsh., betulacea) kernel extracts.  Oriental Pharmacy and Experimental Medicine, 16 (1),45-51; Doi: 10.1007/s13596-015-0212-8

Conferences

  1. Acute and sub-acute toxicity study of Vernonia amygdalina methanol leave extracts in rats. September 2013, Pahang, Malaysia, Scientific Meeting of Malaysian Society of Pharmacology and Physiology.
  2. 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology, Pahang, Malaysia, 6 th September, 2013. Sub-acute (28 days) Toxicity study of methanol leaves extract of Clinacanthus nutans in rats.
  3. Malaysian Pharmaceutical Society Scientific Conference, Kuala Lumpur, October, 2012). Antibacterial Activity of methanolic extract of Clinacanthus Nutans leaf.
  4. Malaysian Pharmaceutical Society Scientific Conference, Kuala Lumpur, 21st-23rd October, 2011. Klebsiella pneumoniae and Candida albicans using disk diffusion method.
  5. Commonwealth Pharmaceutical Association Conference and Malaysian Pharmaceutical Society Scientific Conference, Kuala Lumpur, August 1st - 5 thAugust, 2007. Radical scavenging activity from methanolic extract of Limonia acidissima.
  6. Anti Tumour from Orthosiphon stamineus Benth; Extracts, standardized to betulinic acid. May 19-21, 2005. Putra World Trade Centre, Kuala Lumpur, 16th International, Invention, Innovation, Industrial Design & Technology Exhibition.
  7. Analysis by high-performance liquid chromatography (gradient system) on sinensetin, 3’-hydroxy-5,6,7,4’-tetramethoxyflavone and eupatorin from localities and batches in spray dried Misai kuching extract. Seminar on Medicinal and Aromatic Plants: Current Trends and Perspectives;July 20-21, 2004, Forest Research Institute Malaysia, Kepong.
  8. International Seminar on Natural Products, 13-16 October, 2003, Kuala Lumpur, “The effect of different solvent extraction systems on polyphenols in Orthosiphon stamineus Leaf.”
  9. Malaysian Pharmaceutical Society Scientific Conference, Penang, 31st October – 2 nd November 2002, Penang, “Spectrophotometry (UV) and HPLCdetermination of rosmarinic acid.”

Editorial Board Membership

  1. Journal of Medicinal Chemistry and Toxicology

  2. The Natural Product Journal

  3. Journal of Diabetes Mellitus and Metabolic Syndrome

Journal Reviewers

  • Journal of Pharmaceutical, Chemical and Biological Sciences
  • Archives of Industrial Biotechnology
  • SOJ Chromatographic Science