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Testimonial

Associate Professor Ts Dr Lee Ming Tatt

Professional Technologist under Malaysian Board of Technologists (MBOT)

Associate Professor | Department of Pharmaceutical Biology
Director, Office of Postgraduate Studies

Academic Qualifications

PhD (Physiology)
Bachelor of Science  (Biomedical Sciences)

Areas of Interest
Neuropharmacological study at various brain/nerve regions of laboratory mice/rats.
Animal models of pathological pain, substance abuse, cognitive impairment, movement disorders, etc.
Physiology and pharmacology of preclinical neuropsychiatric disorders.
Pharmacological properties of neuropeptides/neurotransmitters/neuromodulators & their receptors.
Complementary therapy in rodent models.
Publications

No.

Description

JCR Impact Factor

JCR Quartile

1

Werner Sieghart, Lih-Chu Chiou, Margot Ernst, Jure Fabjan, Miroslav Savic and Ming Tatt Lee (2022). α6-containing GABAA receptors: functional roles and therapeutic potentials. Pharmacological Reviews 74 (1), 238-270

25.468

Q1, Pharmacology & Pharmacy

2

Ming Tatt Lee, Ken Mackie and Lih-Chu Chiou (2022). Alternative Pain Management via Endocannabinoids in the Time of the Opioid Epidemic: Peripheral Neuromodulation and Pharmacological Interventions. British Journal of Pharmacology (Accepted for publication in 2022)

9.473

Q1, Pharmacology & Pharmacy

3

Ming Tatt Lee,# Akihiro Mouri,# Hisayoshi Kubota, Hsin-Jung Lee, Man-Hsin Chang, Chen-Yi Wu, Daniel E. Knutson, Marko Mihovilovic, James Cook, Werner Sieghart, Toshitaka Nabeshima and Lih-Chu Chiou (2022). Targeting α6GABAA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models. Biomedicine & Pharmacotherapy 150 (2022) 113022. #Equal contribution

7.419

Q1, Pharmacology & Pharmacy

4

Ming Tatt Lee, Wei-Hao Peng, Hung-Wei Kan, Cheng-Chun Wu, Deng-Wu Wang and Yu-Cheng Ho (2022). Neurobiology of depression: Chronic stress alters the glutamatergic system in the brain - focusing on AMPA receptor.

6.081

Q1, Biochemistry & Molecular Biology

5

Mogana Rajagopal, Alok K. Paul, Ming-Tatt Lee, Anabelle Rose Joykin, Choo-Shiuan Por, Tooba Mahboob, Cristina C. Salibay, Mario S. Torres, Maria Melanie M. Guiang, Mohammed Rahmatullah, Rownak Jahan, Khoshnur Jannat, Polrat Wilairatana, Maria de Lourdes Pereira, Chooi Ling Lim and Veeranoot Nissapatorn (2022). Phytochemicals and Nano-phytopharmaceuticals Use in Skin, Urogenital and Locomotor Disorders: Are We There? Plants 11(9): 1265

4.658

Q1,

Plant Sciences

6

Mayasah Al-Nema, Anand Gaurav, Vannajan Sanghiran Lee, Baskaran Gunasekaran, Ming Tatt Lee, Patrick Okechukwu (2022). Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor. RSC Advances 12: 1576

3.361

Q2, Chemistry; Multi-disciplinary

7

Mayasah Al-Nema, Anand Gaurav, Vannajan Sanghiran Lee, Baskaran Gunasekaran, Ming Tatt Lee, Patrick Okechukwu (2021). Identification of Dual Inhibitor of Phosphodiesterase 1B/10A using Structure-Based Drug Design Approach. Journal of Molecular Liquids 342: 117485

6.633

Q1,

Physics, Atomic, Molecular & Chemical

8

Hung-Ruei Tzeng,# Ming Tatt Lee,# Pi-Chuan Fan, Daniel E. Knutson, Tzu-Hsuan Lai, Werner Sieghart, James Cook and Lih-Chu Chiou (2021). α6GABAA receptor positive modulators alleviate migraine-like grimaces in mice via compensating GABAergic deficits in trigeminal ganglia. Neurotherapeutics 18: 569–585. #Equal contribution

7.620

Q1, Pharmacology & Pharmacy

9

Ming Tatt Lee, Yi-Hung Chen, Ken Mackie and Lih-Chu Chiou (2021). Median nerve stimulation as a non-pharmacological approach to bypass analgesic tolerance to morphine: a proof-of-concept study in mice. The Journal of Pain. 22(3): 300-312

5.820

Q1,

Clinical Neurology

10

Yu-Hsien Chou,# Chia Chun Hor,# Ming Tatt Lee,# Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, and Lih-Chu Chiou (2021). Stress induces reinstatement of extinguished cocaine conditioned place preference by a sequential signaling via neuropeptide S, orexin, and endocannabinoid. Addiction Biology. 26(3): e12971. #Equal contribution

4.280

Q1,

Substance Abuse

 

 

11

Ming Tatt Lee,# Yu-Ting Chiu,# Yu-Chun Chiu,# Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, and Lih-Chu Chiou (2020). Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: A pivotal role in stress-induced analgesia. Journal of Biomedical Science 27:7

8.410

Q1,

Medicine, Research & Experimental

12

Ming Tatt Lee, Hung-Ruei Tzeng, Pi-Chuan Fan, Daniel E. Knutson, Tzu-Hsuan Lai, Werner Sieghart, James Cook, Lih-Chu Chiou (2020). Trigeminal alpha6 subunit containing GABAA receptors as a novel anti-migraine target: A proof-of-concept study. Cephalalgia 40:1_suppl.

6.295

Q1,

Clinical Neurology

13

Audrey Siew Foong Kow, Lai Yen Fong, Leng Wei Khoo, Ji Wei Tan, Khozirah Shaari, Ming Tatt Lee, Daud Ahmad Israf, Faridah Abas, Chau Ling Tham (2020). Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β-hexosaminidase in In Vitro Model of IgE-Mediated Mast Cell Degranulation. Pharmacognosy Magazine 16(69):400-408

1.085

Q4, Chemistry, Medicinal

14

Guan-Ling Lu, Ming Tatt Lee, Lih-Chu Chiou (2019). Orexin-mediated restoration of hippocampal synaptic potentiation in mice with established cocaine conditioned place preference. Addiction Biology 24(6):1153-1166

4.121

Q1,

Substance Abuse

15

Pi-Chuan Fan, Ping-Hung Kuo, Ming Tatt Lee, Shu-Hui Chang, and Lih-Chu Chiou (2019). Plasma calcitonin gene-related peptide: A potential biomarker for diagnosis and therapeutic responses in pediatric migraine. Frontiers in Neurology 10:10

2.889

Q3, Neuroscience

16

Leng Wei Khoo, Audrey Siew Foong Kow, Maulidiani Maulidiani, May Yen Ang, Won Yin Chew, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, and Faridah Abas (2019). 1H-NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS-IFN-γ activated RAW 264.7 macrophages. Phytochemical Analysis 30(1), 46-61

2.772

Q1,

Plant Sciences

17

Palanirajan Vijayaraj Kumar, Marwan Abdelmahmoud Abdelkarim Maki, Yeong Siew Wei, Lee Ming Tatt, Manogaran Elumalai, Shiau-Chuen Cheah, Bharathy Raghavan and Abu Bakar Bin Abdul Majeed (2019). Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles. Current Clinical Pharmacology 14(2):132-140.

Scopus

nil

18

Yi-Hung Chen, Hsin-Jung Lee,# Ming Tatt Lee,# Ya-Ting Wu, Yen-Hsien Lee, Ling-Ling Hwang, Ming-Shiu Hung, Andreas Zimmer, Ken Mackie, and Lih-Chu Chiou (2018). Median Nerve Stimulation Induces Analgesia via Orexin-initiated Endocannabinoid Disinhibition in the Periaqueductal Gray. Proceedings of the National Academy of Sciences of the United States of America. Nov 6; 115 (45):E10720-E10729.

9.580

Q1,

Multi-disciplinary Sciences

19

Pi-Chuan Fan, Tzu-Hsuan Lai, Chia Chun Hor, Ming Tatt Lee, Pokai Huang, Werner Sieghart, Margot Ernst, Daniel E Knutson, James Cook, Lih-Chu Chiou (2018). The α6 Subunit-Containing GABAA Receptor: A Novel Drug Target for Inhibition of Trigeminal Activation. Neuropharmacology 140 1-13

4.367

Q1, Pharmacology & Pharmacy

20

Pokai Huang, Ping-Hung Kuo, Ming Tatt Lee, Lih-Chu Chiou, Pi-Chuan Fan (2018). Age-dependent anti-migraine effects of valproic acid and topiramate in rats. Frontiers in Pharmacology 9:1095

3.845

Q1, Pharmacology & Pharmacy

21

Leng Wei Khoo, Siew Foong Audrey Kow, M. Maulidiani, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, Faridah Abas (2018). Hematological, biochemical, histopathological and 1H-NMR metabolomics application in acute toxicity evaluation of Clinacanthus nutans water leaf extract. Molecules 23(9), 2172

3.060

Q2,

Chemistry; Multi-disciplinary

22

Leng Wei Khoo, Siew Foong Audrey Kow, M. Maulidiani, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, Faridah Abas (2018). Plasma and urine metabolite profiling reveals the protective effect of Clinacanthus nutans in an ovalbumin-induced anaphylaxis model:1H-NMR metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis 158; 438–450

2.983

Q2,

Chemistry, Analytical

 

 

23

Leng Wei Khoo, Siew Foong Audrey Kow, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, and Faridah Abas (2018). A comprehensive review on phytochemistry and pharmacological activities of Clinacanthus nutans (Burm. f) Lindau. Evidence-Based Complementary and Alternative Medicine. Volume 2018, Article ID 9276260.

1.984

Q2,

Integrative & Complementary Medicine

24

Palanirajan Vijayaraj Kumar, Marwan Abdelmahmoud Abdelkarim Maki, Mhd Luay Takahje, Yeong Siew Wei, Lee Ming Tatt and Abu Bakar Bin Abdul Majeed (2018). Detection of Formation of Recombinant Human Keratinocyte Growth Factor Loaded Chitosan Nanoparticles Based on its Optical Properties. Current Nanoscience. 14 (2), 127-135

1.586

Q3,

Material Science, Multi-disciplinary

25

Fui-Ling Voon, Mohd Roslan Sulaiman,# Muhammad Nadeem Akhtar, Mohamad Fauzi Idris, Ahmad Akira, Enoch Kumar Perimal, Daud Ahmad Israf, Lee Ming-Tatt,# (2017). Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats. European Journal of Pharmacology. 794; 127–134. #Equal contribution.

3.040

Q2, Pharmacology & Pharmacy

26

Nur Izzati Ismail, Lee Ming-Tatt, Nordin Lajis, Muhammad Nadeem Akhtar, Ahmad Akira, Enoch Kumar Perimal, Daud Ahmad Israf and Mohd Roslan Sulaiman (2016). Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. Molecules 2016, 21(8), 1077

2.861

Q2,

Chemistry; Organic

27

Jacklin Suloon, Azam Shah Mohamad, Lee Ming-Tatt, Muhammad Nadeem Akhtar, Enoch Kumar Perimal, Ahmad Akira, Daud Ahmad Israf and Mohd Roslan Sulaiman (2015). Hexanic extract of turmeric powder attenuates murine model of induced-nociception and its possible mechanisms of action. African Journal of Traditional, Complementary and Alternative Medicine. 12 (6).

0.553

Q4,

Integrative & Complementary Medicine

28

Lee Ming-Tatt, Shaik Ibrahim Khalivulla, Muhammad Nadeem Akhtar, Nordin Lajis, Enoch Kumar Perimal, Ahmad Akira, Daud Israf Ali, Mohd Roslan Sulaiman (2013). The antihyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP. Pharmacology, Biochemistry and Behavior. 114-115; 58-63

2.820

Q2,

Behavioral Sciences

29

Mohd Nasier Kamaldin, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Nordin Lajis, Enoch Kumar Perimal, Ahmad Akira, Lee Ming-Tatt, Daud Ahmad Israf Ali, Mohd Roslan Sulaiman (2013). Peripheral Antinociception of a Chalcone, Flavokawin B and Possible Involvement of the Nitric Oxide/Cyclic Guanosine Monophosphate/Potassium Channels Pathway. Molecules 18(4), 4209-4220

2.095

Q3,

Chemistry; Organic

30

Yu Zhao Lee,# Lee Ming-Tatt,# Nordin Hj Lajis, Mohd Roslan Sulaiman, Daud Ahmad Israf, Chau Ling Tham (2012). Development and Validation of a Bioanalytical Method for Quantification of 2,6-Bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) in Rat Plasma. Molecules,17, 14555-14564. #Equal contribution

2.438

Q2,

Chemistry; Organic

31

Lee Ming-Tatt, Shaik Ibrahim Khalivulla, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Enoch Kumar Perimal, Mohamed Hanief Khalid, Ahmad Akira, Nordin Lajis, Daud Ahmad Israf, Mohd Roslan Sulaiman (2012). Antinociceptive Activity of a Synthetic Curcuminoid Analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene) cyclohexanone, on Nociception-induced Models in Mice. Basic & Clinical Pharmacology & Toxicology;110(3):275-82.

2.124

Q3, Pharmacology & Pharmacy

32

Enoch Kumar Perimal, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Mohd Hanief Khalid, Ong Hui Ming, Syamimi Khalid, Lee Ming Tatt, Mohd Nasier Kamaldin, Zainul Amiruddin Zakaria, Daud Ahmad Israf, Nordin Lajis, Mohd Roslan Sulaiman (2011). Zerumbone-Induced Antinociception: Involvement of the L-Arginine-Nitric Oxide-cGMP-PKC-K+ATP Channel Pathways. Basic & Clinical Pharmacology & Toxicology,108(3):155-62.

2.124

Q2, Pharmacology & Pharmacy

 

Research

Research project

Grants

Collaboration

Status

Mechanistic study on therapeutic potentials of alpha-tocopherol and tocotrienol-rich palm oil extract in murine model of menopause-associated depression and anxiety

Fundamental Research Grant Scheme (FRGS, MOHE) Principle Investigato

Universiti Putra Malaysia

On-going

Establishing dysmenorrhea-associated neuropsychological phenotypes in mice and potential therapeutic effect of Polyherbal MM-15 Formulation

UCSI University Research Excellence & Innovation Grant (REIG), Principle Investigator

Universiti Putra Malaysia

On-going

Gingerols and Shogaols: Investigations on the role of selective phosphodiesterase 4B inhibition in the respiratory anti-inflammatory activity without central side effects

Fundamental Research Grant Scheme (FRGS, MOHE) Co-Investigator

University Malaya & KIET Group of Institutions

On-going

Evaluation of Polyherbal Formulation, MM-15 for Dual Inhibition of 5-Lipoxygenase (5-LOX)/Cyclooxygenase 2 (COX-2) and 5-LOX derivatives in the Mechanistic Pathway of Primary Dysmenorrhea

UCSI University Research Excellence & Innovation Grant (REIG), Co-Researcher

-

On-going

Evaluation of inhibitory effect of a synthetic curcumonoid derivative on rheumatoid arthritis-induced pain and inflammatory responses

Malaysia Toray Science Foundation (MTSF), Principle Investigator

Universiti Putra Malaysia

Completed

The inhibitory activity of Clinacanthus nutans standardised ethanolic extract on IgE-mediated mast cell activation and anaphylactic reaction

Herbal Research Grant Scheme EPP # 1 (NRGS), Co-Researcher

Universiti Putra Malaysia

Completed

Formulation and Evaluation of Enteric Coated Capsules Filled with Oral Mucoadhesive Palifermin Nanoparticles

Fundamental Research Grant Scheme (FRGS, MOHE) Co-Researcher

Universiti Teknologi MARA

Completed

PhD students (Current)

  • Chen Li (2021)
  • Liang Gengfan (2021)
  • Mayasah Al-Nema (Co-supervision, 2018)
  • Yap Vi Lien (Co-supervision, 2021)
  • Tan Li Fang (Co-supervision, 2021)

 

PhD students (Completed)

  • Audrey Kow (UPM, Co-supervision, 2016)

 

Master students (Current)

  • N/A

 

Master students (Completed)

  • Voon Fui Ling (UPM, Co-supervision, 2014)
  • Mohd Fauzi bin Mohd Idris (UPM, Co-supervision, 2014)

 

Undergraduate students (Current)

  • Lai Jing Yung (2021)
  • Helena Ngui Hui Lin (2021)
  • Low Yee Ching (2021)

 

Undergraduate students (Completed)

  • Goh Chuhn Hung (2016)