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Faculty of Medicine & Health Sciences
Faculty of Medicine & Health Sciences

Dr. Siak Pui Yan

Dr Siak Pui Yan

Post-Doctoral Research Fellow

Academic Qualifications

PhD in Science
BSc in Biotechnology (Hons)
Diploma in Biotechnology

Areas of Interest
Cancer Vaccine: orally administered recombinant Lactococcus Lactis secreting modified mutant K-ras mimotopes as a potential colorectal cancer vaccine
Cancer Biomarker(s): Identifying the signature(s) biomarker of early metastasis event in nasopharyngeal carcinoma using heterotypic multicellular tumour spheroid
Research

Current Research Project

  1. Identifying the signature(s) biomarker of early metastasis event in nasopharyngeal carcinoma using heterotypic multicellular tumour spheroid
  2. Characterisation of Tumour Microenvironment in EBV-positive Nasopharyngeal Carcinoma Progression from growth, invasion to metastasis

Publications

  1. Zhi Yi Su, Pui Yan Siak, Chee Onn Leong, Boon-Peng Hoh, Shiau-Chuen Cheah, (2022). Nasopharyngeal Carcinoma and Its Microenvironment: Past, Current, and Future Perspectives. Frontier in Ocology, 12. doi:10.3389/fonc.2022.840467. 
  2. Pui Yan Siak, Alan Soo-Beng Khoo, Chee Onn Leong, Boon-Peng Hoh, Shiau-Chuen Cheah, (2021). Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma. Cancers, 13(14):3490. doi: 10.3390/cancers13143490. 2021 
  3. Pui Yan Siak, Kuan Yee Wong, Adelene Ai-Lian Song, Raha Abdul Rahim, Lionel Lian Aun In, (2021). K-Ras Peptide mimotope induces antigen specific Th1 and B-Cell immune responses against G12A-mutated K-Ras antigen in Balb/c mice. Vaccines, 9(3):195. doi: 10.3390/vaccines9030195.
  4. Winfrey Pui Yee Hoo, Pui Yan Siak, Nur Aqlili Riana Alias, Jia Jia Wong, Ee Wern Tan, Adelene Ai-Lian Song, Raha Abdul Rahim, Lionel Lian Aun In, (2020). K-ras peptide mimotope induces a humoral lmmune response against G12V K-ras antigen in BALB/c mice. Asia-Pacific Journal of Molecular Biology and Biotechnology, 28(3):22-35. doi: 10.35118/apjmbb.2020.028.3.03
  5. Winfrey Pui Yee Hoo, Pui Yan Siak, Lionel L.A. In, (2020). In Silico-Guided Sequence Modification of Epitopes in Cancer Vaccine Development. Methods in Molecular Biology, 2131, 213-228. doi: 10.1007/978-1-0716-0389-5_10.
  6. Winfrey Pui Yee Hoo, Pui Yan Siak, Lionel Lian Aun In, (2019). Overview of current immunotherapies targeting mutated KRAS cancers. Current Topics in Medicinal Chemistry, 19(23), 2158-2175. doi: 10.2174/1568026619666190904163524. 
  7. Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, (2018). In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens. PeerJ, 6: e5056. doi: 10.7717/peerj.5056.

Conference

  1. Graduate Research Symposium 2019, Organized by Faculty of Health and Medical Sciences, Taylor’s University, Malaysia.

Award and Recognition

  1. InnoCentive Premium Challenge Award Winner – Ref. No. 9933830: Delivery of Biomolecules to the Gastrointestinal Tract. Organized by InnoCentive, USA.