
Dr Tiong Yee Lian
Post-Doctoral Research Fellow
Academic Qualifications
PhD in Medical and Health Science
Master of Science
Bachelor of Science (Hons) in Biotecnology
Publications
- Chok, K. C., Ng, M. G., Ng, K. Y., Koh, R. Y., Tiong, Y. L., Chye S. M. (2021). Edible bird’s nest: recent updates and industry insight based on laboratory findings. Frontiers in Pharmacology, 12:746656.
- Tiong, Y. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Chye, S. M. (2020). Melatonin promotes Schwann cell dedifferentiation and proliferation through Ras/Raf/ERK pathway and glial cell-derived neurotrophic factor expression. Experimental and Therapeutic Medicine, 20(5):16.
- Tiong, Y. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Chye, S. M. (2020). Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells. Hormone Molecular Biology and Clinical Investigation, 41(4).
- Kasi, R., Yeo, P. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Tiong, Y. L., Chye, S. M. (2020). Melatonin induces apoptosis and inhibits the proliferation of cancer cells via reactive oxygen species-mediated MAPK and mTOR pathways. Clinical Cancer Drugs, 7(2): 44-56.
- Tiong, Y. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Chye, S. M. (2019). Melatonin prevents oxidative stress-induced mitochondrial dysfunction and apoptosis in high glucose-treated Schwann cells via Bcl2, NF-kB, mTOR, Wnt signaling pathways. Antioxidants, 8(7): 198.
- Ng, P. Y., Chye, S. M., Tiong, Y. L., Chan, C. W., Tab, K. W., Ooi, I. H., Ng, C. H. (2018). Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies. Transition Metal Chemistry, 43: 479-496.
- Koh, R. Y., Lim, F. P., Ling, L. S. Y., Ng, C. P. L., Liew, S. F., Yew, M. Y., Tiong, Y. L., Ling, A. P. K., Chye, S. M., Ng, K. Y. (2017). Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines. Oncology Letters, 14(4): 4957-4964.
- Ng, P. Y., Chye, S. M., Ng, C. H., Koh, R. Y., Tiong, Y. L., Pui, L. P., Tan, Y. H., Lim, C. S., Ng, K. Y. (2017). Clinacanthus Nutans hexane extracts induce apoptosis through a caspase-dependent pathway in human cancer cell lines. Asia Pacific Journal of Cancer Prevention, 18(4): 917-926.
- Koh, R. Y., Sim, Y. C., Toh, H. J., Liam, L. K., Ong, R. S., Yew, M. Y., Tiong, Y. L., Ling, A. P., Chye, S. M., Ng, K. Y. (2015). Cytotoxic and apoptogenic effect of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells. Molecular Medicine Reports, 12(4): 6293-6299.
- Ng, C. H., Kong, K. M., Tiong, Y. L., Maah, J. M., Sukram, N., Ahmad, M., Alan, S. B. K. (2014). Selective anticancer copper(ii)-mixed ligand complexes: targeting of ROS and proteosomes. Metallomics, 1756-5901, 6(4) : 892-906.
- Chye, S. M., Tiong, Y. L., Yip, W. K., Koh, R. Y., Len, Y. W., Seow, H. F., Ng, K. Y., Ranjit, D. A., Chen, S. C. (2014). Apoptosis induced by para-phenylenediamine involves formation of ROS and activation of p38 and JNK in Chang liver cells. Environmental Toxicology, 29(9) : 981-990.
- Leong, C. O., Chen, S.C., Tiong, Y. L., Loh, V. F., Ng, C. H., Chye, S. M. (2014). 4-Chloro-1,2-phenylenediamine induces apoptosis in Mardin-Darby canine kidney cells via activation of caspases. Environmental Toxicology, 29(6): 655-664.
- Chin, L. F., Kong, S. M., Seng, H. L., Tiong, Y. L., Neo, K. E., Maah, M. J., Khoo, A. S., Ahmad, M., Hor, T. S., Lee, H. B., San, S. L., Chye, S. M., Ng, C. H. (2012). [Zn(phen)(O,N,O)(H(2)O)] and [Zn(phen)(O,N)(H(2)O)] with O,N,O is 2,6-dipicolinate and N,O is L: -threonine: synthesis, characterization, and biomedical properties. Journal of Biological Inorganic Chemistry, 17(7): 1093-1105.
- Chen, S. C., Chen, C. H., Tioh, Y. L., Zhong, P. Y., Lin, Y. S., Chye, S. M. (2010). Para- phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced Caspase-8 and -9 activities in Mardin-Darby canine kidney cells. Toxicology in Vitro, 24(4): 1197–1202.