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Faculty of Applied Science
Faculty of Applied Sciences

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Research Impact:
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Dr Tiong Yee Lian

Post-Doctoral Research Fellow

Academic Qualifications

PhD in Medical and Health Science
Master of Science                              
Bachelor of Science (Hons) in Biotecnology

Publications

  1. Chok, K. C., Ng, M. G., Ng, K. Y., Koh, R. Y., Tiong, Y. L., Chye S. M. (2021). Edible bird’s nest: recent updates and industry insight based on laboratory findings. Frontiers in Pharmacology, 12:746656.
  2. Tiong, Y. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Chye, S. M. (2020). Melatonin promotes Schwann cell dedifferentiation and proliferation through Ras/Raf/ERK pathway and glial cell-derived neurotrophic factor expression. Experimental and Therapeutic Medicine, 20(5):16.
  3. Tiong, Y. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Chye, S. M. (2020). Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells. Hormone Molecular Biology and Clinical Investigation, 41(4).
  4. Kasi, R., Yeo, P. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Tiong, Y. L., Chye, S. M. (2020). Melatonin induces apoptosis and inhibits the proliferation of cancer cells via reactive oxygen species-mediated MAPK and mTOR pathways. Clinical Cancer Drugs, 7(2): 44-56.
  5. Tiong, Y. L., Ng, K. Y., Koh, R. Y., Gnanajothy, P., Chye, S. M. (2019). Melatonin prevents oxidative stress-induced mitochondrial dysfunction and apoptosis in high glucose-treated Schwann cells via Bcl2, NF-kB, mTOR, Wnt signaling pathways. Antioxidants, 8(7): 198.
  6. Ng, P. Y., Chye, S. M., Tiong, Y. L., Chan, C. W., Tab, K. W., Ooi, I. H., Ng, C. H. (2018). Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies. Transition Metal Chemistry, 43:  479-496.
  7. Koh, R. Y., Lim, F. P., Ling, L. S. Y., Ng, C. P. L., Liew, S. F., Yew, M. Y., Tiong, Y. L., Ling, A. P. K., Chye, S. M., Ng, K. Y. (2017). Anticancer mechanisms of Strobilanthes crispa Blume hexane extract on liver and breast cancer cell lines. Oncology Letters, 14(4): 4957-4964.
  8. Ng, P. Y., Chye, S. M., Ng, C. H., Koh, R. Y., Tiong, Y. L., Pui, L. P., Tan, Y. H., Lim, C. S., Ng, K. Y. (2017). Clinacanthus Nutans hexane extracts induce apoptosis through a caspase-dependent pathway in human cancer cell lines. Asia Pacific Journal of Cancer Prevention, 18(4): 917-926.
  9. Koh, R. Y., Sim, Y. C., Toh, H. J., Liam, L. K., Ong, R. S., Yew, M. Y., Tiong, Y. L., Ling, A. P., Chye, S. M., Ng, K. Y. (2015). Cytotoxic and apoptogenic effect of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells. Molecular Medicine Reports, 12(4): 6293-6299.
  10. Ng, C. H., Kong, K. M., Tiong, Y. L., Maah, J. M., Sukram, N., Ahmad, M., Alan, S. B. K. (2014). Selective anticancer copper(ii)-mixed ligand complexes: targeting of ROS and proteosomes. Metallomics, 1756-5901, 6(4) : 892-906.
  11. Chye, S. M., Tiong, Y. L., Yip, W. K., Koh, R. Y., Len, Y. W., Seow, H. F., Ng, K. Y., Ranjit, D. A., Chen, S. C. (2014). Apoptosis induced by para-phenylenediamine involves formation of ROS and activation of p38 and JNK in Chang liver cells. Environmental Toxicology, 29(9) : 981-990.
  12. Leong, C. O., Chen, S.C., Tiong, Y. L., Loh, V. F., Ng, C. H., Chye, S. M. (2014). 4-Chloro-1,2-phenylenediamine induces apoptosis in Mardin-Darby canine kidney cells via activation of caspases.  Environmental Toxicology,  29(6): 655-664.
  13. Chin, L. F., Kong, S. M., Seng, H. L., Tiong, Y. L., Neo, K. E., Maah, M. J., Khoo, A. S., Ahmad, M., Hor, T. S., Lee, H. B., San, S. L., Chye, S. M., Ng, C. H. (2012). [Zn(phen)(O,N,O)(H(2)O)] and [Zn(phen)(O,N)(H(2)O)] with O,N,O is 2,6-dipicolinate and N,O is L: -threonine: synthesis, characterization, and biomedical properties. Journal of Biological Inorganic Chemistry, 17(7): 1093-1105.
  14. Chen, S. C., Chen, C. H., Tioh, Y. L., Zhong, P. Y., Lin, Y. S., Chye, S. M. (2010).  Para- phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced Caspase-8 and -9 activities in Mardin-Darby canine kidney cells. Toxicology in Vitro, 24(4): 1197–1202.