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Professor Dr. Hoh Boon Peng

Professor Dr. Hoh Boon Peng

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Professor Dr. Hoh Boon Peng

Professor of Human Genetics

Professor
 

Academic Qualifications

PhD
BSc (Hons)

Areas of Interest
Population Genetics
Genetics of complex diseases
Archaic human genome analysis
Professional Bodies

  1. Genetic Society Malaysia
  2. Human Genome Organization (HUGO)

Research

Research Grants

  1. Name of grant: FRGS
    Funder: MOHE/MOE
    Project Title: Analysis of Archaic Genomes Introgression and Natural Selection in Hunter-gatherers Negrito from Peninsular Malaysia
    Code: FRGS/1/2015/ST03/UCSI/02/1
    Duration: 3 years
    Role: Principal investigator
    Amount: RM155000
    Status: Completed
  2. Name of grant: FRGS
    Funder: MOHE/MOE
    Project Title: Natural selection and local adaptation of malaria resistance and cholesterol levels in hunter-gatherer Negritos from Peninsular Malaysia: an alternative model to Darwinism Medicine
    Code: FRGS/2/2014/ST03/UITM/02/1
    Duration: 3 years
    Role: Principal investigator / Co-Researcher
    Amount: RM131000
    Status: Completed

 

Current Research Project

  1. Migration history and natural selection of Southeast Asian populations
  2. Genetics of Hypertension
  3. Host Genetics of Dengue

Publications

  1. Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension. BP Hoh, TA Rahman, K Yusoff Hereditas 156 (1), 1
  2. Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia. Nan Jiun Yap, Indra Vythilingam, Boon Peng Hoh, Xiang Ting Goh, Azdayanti Muslim, Romano Ngui, Yamuna Rajoo, Seow Huey Choy, Timothy William, Tsin Wen Yeo, Yvonne Ai-Lian Lim. Parasites & vectors 11 (1), 626
  3. Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia. Atiqah Mokhsin, Siti Shuhada Mokhtar, Aletza Mohd Ismail, Fadzilah M Nor, Syahrul Azlin Shaari, Hapizah Nawawi, Khalid Yusoff, Thuhairah Abdul Rahman, Boon Peng Hoh. BMJ open 8 (12), e021580
  4. Differential Positive Selection At Malaria Resistance Genes In Three Indigenous Populations Of Peninsular Malaysia. Xuanyao Liu, Yushimah Yunus, Dongsheng Lu, Farhang Aghakhanian, WoeiYuh Saw, Lian Deng, Mohammad Ali, Xu Wang, Fadzilah Mohd Nor, Thuhairah Abdul Rahman, Syahrul Azlin Shaari, Mohd Zaki Salleh, Maude E Phipps, Rick Twee-Hee Ong, Shuhua Xu, Yik- Ying Teo, Boon-Peng Hoh. 2015 Human genetics 134 (4), 375-392 
  5. Cardio-Metabolic Health in Indigenous Populations: Consequence of Socio-economy Progress in Distinct Indigenous Tribes of South East Asia. Maude E Phipps, Kevin KL Chan, Rakesh Naidu, Nazaimoon W Mohamad, Boon-Peng Hoh, Kia-Fatt Quek, Badariah Ahmad, Siti MI Harnida, Anuar ZM Zain, Khalid A Kadir. 2015. BMC public health 15 (1), 47
  6. Unravelling the Genetic History of Negritos and Indigenous populations of Southeast Asia. Farhang Aghakhanian, Yushima Yunus, Rakesh Naidu, Timothy Jinam, Andrea Manica, Hoh Boon Peng, and Maude E. Phipps. 2015. Genome Biology and Evolution. evv065 
  7. Common Variants of Chemokines Genes CXCL10 and CXCL11 and their Receptor Gene CXCR3 are Associated with Vascular Permeability of Dengue Infection in Peninsular Malaysia. BP Hoh, Umi SH, Zuraihan Z, Zaiharina MZ, Rafidah Hanim MS, Mahiran M, Nik Khairudin NY, Benedict Sim, Masliza Z, Christopher Lee, Sazaly AB. 2015. Human Immunology. http://dx.doi.org/10.1016/j.humimm.2015.03.019 
  8. Quantitation of Serum Fc Gamma Receptor I Antibody in Patients with Dengue. Zaiharina MZ, Zuraihan Z, Abu Thalhah AZ, Benedict LH Sim, Masliza Zaid, Christopher KC Lee, Fadzilah MN, Sazaly AB, Hoh BP. 2015. BMC Journal of Negative Results in Biomedicine. 14 (1), doi:10.1186/s12952- 014-0020-6 
  9. Comparison of genotyping assay for accurate copy number measurement of FCGR3A and 3B. Umi Shakina Haridan, Zuraihan Zakaria, Umairah Mokhtar, Lee R. Machado, Abu Thalhah Abdul Aziz, Siti Khadijah Jusoh, Rafidah Hanim Shueb, Masliza Zaid, Benedict Sim, Christopher Lee, Suhaili Abu Bakar, Sazaly Abu Bakar, Edward J.Hollox, BP Hoh. 2015. PLOS ONE. 10, e0116791. doi:10.1371/journal.pone.01167 
  10. Human Gene Copy Number Variation and Infectious Disease. BP Hoh, EJ Hollox. 2014. Human Genetics. 133 (10), 1217-1233 
  11. The Population Genomic Landscape of Human Genetic Structure, Admixture History and Local Adaptation in Peninsular Malaysia. Lian Deng, Hoh Boon Peng, Dongsheng Lu, Ruiqing Fu, Maude E. Phipps, Shilin Li, Ab Rajab Nur-Shafawati, Wan Isa Hatin, Endom Ismail, Siti Shuhada Mokhtar, Li Jin, Bin Alwi Zilfalil, Christian R Marshall, Stephen W Scherer, Fahd Al- Mulla, Shuhua Xu. Human Genetics. 2014. DOI 10.1007/s00439-014-1459-8  
  12. Novel Population Specific Autosomal Copy Number Variation And Its Functional Analysis Amongst Negritos From Peninsular Malaysia. Siti Shuhada Mokhtar, Christian R Marshall, Maude E Phipps, Bhooma Thiruvahindrapuram, Anath C Lionel, Stephen W Scherer, Hoh Boon Peng. PLOS ONE. 2014. DOI 10.1371/journal.pone.0100371 
  13. Mapping Human Genetic Diversity in Asia. The HUGO Pan-Asian SNP Consortium et al. 2009. Science 326: 1541- 1545 

Awards and Recognitions

  1. Ten Outstanding Young Malaysian Award (Academic Achievement & Accomplishment) 2013
  2. 2017 Chinese Academy of Sciences, President's International Fellowship Initiatives - Visiting Professorship

Networks and Collaborations on Research

  1. Asian Diversity Project
  2. International Human Phenomics Consortium
  3. Harvard Medical School
  4. The Centre for Applied Genomics (TCAG), SickKids Hospital, Toronto
  5. National University Singapore
  6. Chinese Academy of Sciences