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Faculty of Applied Science
Faculty of Applied Sciences

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Professor Dr Shamala Devi A/P K.C. Sekaran, FASc

Professor

Academic Qualifications

PhD in Immunovirology
Master in Counselling
Master in Immunoparasitology
BSc in Genetics & Microbiology
BSc in Biology

Areas of Interest
Virology & Immunology - dengue virus, CMV, BK, diagnostics, immune responses, cytokine profiles
Virology - Dengue Diagnostics and Pathogenesis
Bacteriology - Antibiotic resistance mechanisms and detection
Virology - Antiviral screening, drug discovery
Publications

  1. Gladstone, R. A., Siira, L., Brynildsrud, O. B., Vestrheim, D. F., Turner, P., Clarke, S. C., Srifuengfung, S., Ford, R., Lehmann, D., Egorova, E., Voropaeva, E., Haraldsson, G., Kristinsson, K. G., McGee, L., Breiman, R. F., Bentley, S. D., Sheppard, C. L., Fry, N. K., Corander, J., Toropainen, M., … Global Pneumococcal Sequencing Consortium (2022). International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease. Vaccine, 40(7), 1054–1060.
  2. Manikam R, Mui WS, Kong YY, Raju CS, Sekaran SD. Differential Analysis and Putative Roles of Genes, Cytokines and Apoptotic Proteins in Blood Samples of Patients with Respiratory Viral Infections: A Single Center Study. J Pure Appl Microbiol. 2021;15(4):2448-2461. doi: 10.22207/JPAM.15.4.72
  3. Looi, K. W., Matsui, Y., Kono, M., Samudi, C., Kojima, N., Ong, J. X., Tan, C. A., Ang, C. S., Tan, P., Shamnugam, H., Sekaran, S. D., Syed Omar, S. F., & Lum, L. (2021). Evaluation of immature platelet fraction as a marker of dengue fever progression. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 110, 187–194.
  4. Guad, R. M., Mangantig, E., Low, W. Y., Taylor-Robinson, A. W., Azzani, M., Sekaran, S. D., Sim, M. S., & Azizan, N. (2021). Development and validation of a structured survey questionnaire on knowledge, attitude, preventive practice, and treatment-seeking behaviour regarding dengue among the resident population of Sabah, Malaysia: an exploratory factor analysis. BMC infectious diseases, 21(1), 893.
  5. Chan, S.M.; Khoo, K.S.; Sekaran, S.D.; Sit, N.W. Mode-Dependent Antiviral Activity of Medicinal Plant Extracts against the Mosquito-Borne Chikungunya Virus. Plants 2021, 10, 1658.
  6. Chong, Z. L., Soe, H. J., Ismail, A. A., Mahboob, T., Chandramathi, S., & Sekaran, S. D. (2021). Evaluation of the Diagnostic Accuracy of a New Biosensors-Based Rapid Diagnostic Test for the Point-Of-Care Diagnosis of Previous and Recent Dengue Infections in Malaysia. Biosensors, 11(5), 129.
  7. Guad, R. M., Wu, Y. S., Aung, Y. N., Sekaran, S. D., Wilke, A., Low, W. Y., Sim, M. S., Carandang, R. R., Jeffree, M. S., Taherdoost, H., Sunggip, C., Lin, C., Murugaiah, C., Subramaniyan, V., & Azizan, N. (2021). Different Domains of Dengue Research in Malaysia: A Systematic Review and Meta-Analysis of Questionnaire-Based Studies. International journal of environmental research and public health, 18(9), 4474.
  8. D'Aeth, J. C., van der Linden, M. P., McGee, L., de Lencastre, H., Turner, P., Song, J. H., Lo, S. W., Gladstone, R. A., Sá-Leão, R., Ko, K. S., Hanage, W. P., Breiman, R. F., Beall, B., Bentley, S. D., Croucher, N. J., & GPS Consortium (2021). The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci. eLife, 10, e67113.
  9. Om Parkash 1,2, Muhammad Amiruddin Abdullah 1, Chan Yean Yean 1, Shamala Devi Sekaran 3 and Rafidah Hanim Shueb. (2021) Development and Evaluation of an Electrochemical Biosensor for Detection of Dengue-Specific IgM Antibody in Serum Samples
  10. Zika virus and the blood-brain barrier Rishya Manikam, Soe Hui Jen, Amni Adilah Ismail, Chandramathi Samudi Raju, and Shamala Devi Sekaran. 2021. In Zika Virus Biology, Transmission, and Pathways The Neuroscience of Zika Virus. Chapter 19: 209-217 

Research

Current Research Project

  1. HLA and non-HLA genetic susceptibility to dengue infection in sabah population.
  2. Characterisation and evaluation of aptamer based Screen Printed Electrode (SPE) biosensor derivatives as a potential method for differentiating antibodies among Flaviviruses.
  3. Investigations into the Mechanisms of Vascular Leakage in Severe Dengue that are Associated with Diabetes and Obesity.

Conference

  1. Speaker, The many unanswered questions about Dengue. Inaugural FAScinate Talk, Academy Science Malaysia. 12 November 2019. 
  2. Speaker, Anticancer properties of Four Phyllanthus spp. Hunan Innovative International Conference on Biomedicine and Chinese Medicine, Hunan University of Chinese Traditional Medicine,  25 October 2019.
  3. Speaker, Antimicrobial properties of Four Phyllanthus spp. 1st International Symposium on Medical resources along One Belt and One Road, Guangxi University,  21 October 2019.
  4. Speaker, Obesity in Dengue. National Dengue Conference, Ministry of Health & TIDREC, 7 to 8 July 2019.
  5. Speaker, Dengue Diagnostics. National Dengue Conference, Ministry of Health & TIDREC, 7 to 8 July 2019.

Award and Recognition

  1. Fellow of The Royal College of Pathologists (2020)
  2. Fellow of Academy of Sciences (2021)
  3. Exper Panel for MOSTI Research & Development (R&D) Fund, Ministry of Science, Technology and Innovation (MOSTI) (2021)
  4. Validators  for Malaysian Research and Development Classification System (MRDCS), Ministry of Science, Technology and Innovation (MOSTI) (2021)