APPLY NOW VIRTUAL TOUR

Research Impact:

Google Scholar
Scopus

Associate Professor Ts. Dr. Lee Ming Tatt

Professional Technologist under Malaysian Board of Technologists (MBOT)

Associate Professor | Department of Pharmaceutical Biology
Director, Office of Postgraduate Studies

Academic Qualifications

PhD (Physiology)
Bachelor of Science  (Biomedical Sciences)

Areas of Interest
Neuropharmacological study at various brain/nerve regions of laboratory mice/rats.
Animal models of pathological pain, substance abuse, cognitive impairment, movement disorders, etc.
Complementary therapy in rodent models.
Pharmacological properties of neuropeptides/neurotransmitters/neuromodulators & their receptors.
Publications

1. Hung-Ruei Tzeng*, Ming Tatt Lee*, Pi-Chuan Fan, Daniel E. Knutson, Tzu-Hsuan Lai, Werner Sieghart, James Cook and Lih-Chu Chiou (2021). α6GABAA receptor positive modulators alleviate migraine-like grimaces in mice via compensating GABAergic deficits in trigeminal ganglia. Neurotherapeutics 18: 569–585 (IF 2020 = 7.620; JCR Q1, Pharmacology & Pharmacy) *Equal contribution.

2. Ming Tatt Lee, Yi-Hung Chen, Ken Mackie and Lih-Chu Chiou (2021). Median nerve stimulation as a non-pharmacological approach to bypass analgesic tolerance to morphine: a proof-of-concept study in mice. The Journal of Pain. 22(3): 300-312 (IF 2020 = 5.820; JCR Q1, Clinical Neurology)

3. Yu-Hsien Chou*, Chia Chun Hor*, Ming Tatt Lee*, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, and Lih-Chu Chiou (2021). Stress induces reinstatement of extinguished cocaine conditioned place preference by a sequential signaling via neuropeptide S, orexin and endocannabinoid. Addiction Biology 26(3): e12971. (IF 2020 = 4.280; JCR Q1, Substance Abuse) *Equal contribution

4. Mayasah Al-Nema, Anand Gaurav, Vannajan Sanghiran Lee, Baskaran Gunasekaran, Ming Tatt Lee, Patrick Okechukwu (2021). Identification of Dual Inhibitor of Phosphodiesterase 1B/10A using Structure-Based Drug Design Approach. Journal of Molecular Liquids 342: 117485 (IF 2020: 6.165, JCR Q1,Physics, atomic, molecular & chemical)

5. Ya-Hsien Huang, Ming Tatt Lee, Werner Sieghart, Daniel E. Knutson, Laurin R. Wimmer, Dishary Sharmin, James Cook, Marko D. Mihovilovic, and Lih-Chu Chiou (2021). Positive modulation of cerebellar α6GABAA receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice (Preprint). bioRxiv. DOI: 10.1101/2021.04.19.440397

6. Ming Tatt Lee*, Yu-Ting Chiu*, Yu-Chun Chiu*, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, and Lih-Chu Chiou (2020). Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: A pivotal role in stress-induced analgesia. Journal of Biomedical Science 27:7 (IF 2020 = 8.410; JCR Q1, Medicine, Research & Experimental) *Equal contribution

7. Audrey Siew Foong Kow, Lai Yen Fong, Leng Wei Khoo, Ji Wei Tan, Khozirah Shaari, Ming Tatt Lee, Daud Ahmad Israf, Faridah Abas, Chau Ling Tham (2020). Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β-hexosaminidase in In Vitro Model of IgE-Mediated Mast Cell Degranulation. Pharmacognosy Magazine 16(69):400-408 (IF 2020 = 1.085; JCR Q4, Chemistry, Medicinal)

8. Guan-Ling Lu, Ming Tatt Lee, Lih-Chu Chiou (2019). Orexin-mediated restoration of hippocampal synaptic potentiation in mice with established cocaine conditioned place preference. Addiction Biology 24(6):1153-1166. (IF 2019 = 4.121; JCR Q1, Substance Abuse)

9. Pi-Chuan Fan, Ping-Hung Kuo, Ming Tatt Lee, Shu-Hui Chang, and Lih-Chu Chiou (2019). Plasma calcitonin gene-related peptide: A potential biomarker for diagnosis and therapeutic responses in pediatric migraine. Frontiers in Neurology 10:10 (IF 2019 = 2.889; JCR Q3, Neuroscience)

10. Leng Wei Khoo, Audrey Siew Foong Kow, Maulidiani Maulidiani, May Yen Ang, Won Yin Chew, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, and Faridah Abas (2019). 1H-NMR metabolomics for evaluating the protective effect of Clinacanthus nutans (Burm. f) Lindau water extract against nitric oxide production in LPS-IFN-γ activated RAW 264.7 macrophages. Phytochemical Analysis 30(1), 46-61 (IF 2019 = 2.772, JCR Q1, Plant Sciences)

11. Palanirajan Vijayaraj Kumar, Marwan Abdelmahmoud Abdelkarim Maki, Yeong Siew Wei, Lee Ming Tatt, Manogaran Elumalai, Shiau-Chuen Cheah, Bharathy Raghavan and Abu Bakar Bin Abdul Majeed (2019). Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles. Current Clinical Pharmacology 14(2):132-140.

12. Yi-Hung Chen, Hsin-Jung Lee*, Ming Tatt Lee*, Ya-Ting Wu, Yen-Hsien Lee, Ling-Ling Hwang, Ming-Shiu Hung, Andreas Zimmer, Ken Mackie, and Lih-Chu Chiou (2018). Median Nerve Stimulation Induces Analgesia via Orexin-initiated Endocannabinoid Disinhibition in the Periaqueductal Gray. Proceedings of the National Academy of Sciences of the United States of America. Nov 6; 115 (45):E10720-E10729. (IF 2018 = 9.580, JCR Q1, Multidisciplinary Sciences) *Equal contribution

13. Pi-Chuan Fan, Tzu-Hsuan Lai, Chia Chun Hor, Ming Tatt Lee, Pokai Huang, Werner Sieghart, Margot Ernst, Daniel E Knutson, James Cook, Lih-Chu Chiou (2018). The α6 Subunit-Containing GABAA Receptor: A Novel Drug Target for Inhibition of Trigeminal Activation. Neuropharmacology 140 1-13 (IF 2018 = 4.367; JCR Q1, Pharmacology & Pharmacy)

14. Pokai Huang, Ping-Hung Kuo, Ming Tatt Lee, Lih-Chu Chiou, Pi-Chuan Fan (2018). Age-dependent anti-migraine effects of valproic acid and topiramate in rats. Frontiers in Pharmacology 2018 Sep 25;9:1095 (IF 2018 = 3.845; JCR Q1, Pharmacology & Pharmacy)

15. Leng Wei Khoo, Siew Foong Audrey Kow, M. Maulidiani, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, Faridah Abas (2018). Hematological, biochemical, histopathological and 1H-NMR metabolomics application in acute toxicity evaluation of Clinacanthus nutans water leaf extract. Molecules 23(9), 2172 (IF 2018 = 3.060; JCR Q2; Chemistry; Multidisciplinary)

16. Leng Wei Khoo, Siew Foong Audrey Kow, M. Maulidiani, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, Faridah Abas (2018). Plasma and urine metabolite profiling reveals the protective effect of Clinacanthus nutans in an ovalbumin-induced anaphylaxis model:1H-NMR metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis 158 (2018) 438–450 (IF 2018 = 2.983; JCR Q2, Chemistry, Analytical)

17. Leng Wei Khoo, Siew Foong Audrey Kow, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, and Faridah Abas (2018). A comprehensive review on phytochemistry and pharmacological activities of Clinacanthus nutans (Burm. f) Lindau. Evidence-Based Complementary and Alternative Medicine. Volume 2018, Article ID 9276260. (IF 2018 = 1.984; JCR Q2, Integrative & Complementary Medicine)

18. Palanirajan Vijayaraj Kumar, Marwan Abdelmahmoud Abdelkarim Maki, Mhd Luay Takahje, Yeong Siew Wei, Lee Ming Tatt and Abu Bakar Bin Abdul Majeed (2018). Detection of Formation of Recombinant Human Keratinocyte Growth Factor Loaded Chitosan Nanoparticles Based on its Optical Properties. Current Nanoscience. 14 (2), 127-135 (IF 2018 = 1.586; JCR Q3, Material Science, Multidisciplinary)

19. Fui-Ling Voon, Mohd Roslan Sulaiman*, Muhammad Nadeem Akhtar, Mohamad Fauzi Idris, Ahmad Akira, Enoch Kumar Perimal, Daud Ahmad Israf, Lee Ming-Tatt* (2017). Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats. European Journal of Pharmacology. Vol 794, 5 January 2017, Pages 127–134 (IF 2017 = 3.040; JCR Q2, Pharmacology & Pharmacy) *Equal contribution.

20. Nur Izzati Ismail, Lee Ming-Tatt, Nordin Lajis, Muhammad Nadeem Akhtar, Ahmad Akira, Enoch Kumar Perimal, Daud Ahmad Israf and Mohd Roslan Sulaiman (2016). Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. Molecules 2016, 21(8), 1077 (IF 2016 = 2.861; JCR Q2; Chemistry; Organic)

21. Jacklin Suloon, Azam Shah Mohamad, Lee Ming-Tatt, Muhammad Nadeem Akhtar, Enoch Kumar Perimal, Ahmad Akira, Daud Ahmad Israf and Mohd Roslan Sulaiman (2015). Hexanic extract of turmeric powder attenuates murine model of induced-nociception and its possible mechanisms of action. African Journal of Traditional, Complementary and Alternative Medicine. Vol 12, No 6. (IF 2015 = 0.553; JCR Q4, Integrative & Complementary Medicine)

22. Lee Ming-Tatt, Shaik Ibrahim Khalivulla, Muhammad Nadeem Akhtar, Nordin Lajis, Enoch Kumar Perimal, Ahmad Akira, Daud Israf Ali, Mohd Roslan Sulaiman (2013). The antihyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP. Pharmacology, Biochemistry and Behavior. 2013 Dec, 114-115, 58-63 (IF 2013 = 2.820; JCR Q2; Behavioral Sciences)

23. Mohd Nasier Kamaldin, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Nordin Lajis, Enoch Kumar Perimal, Ahmad Akira, Lee Ming-Tatt, Daud Ahmad Israf Ali, Mohd Roslan Sulaiman (2013). Peripheral Antinociception of a Chalcone, Flavokawin B and Possible Involvement of the Nitric Oxide/Cyclic Guanosine Monophosphate/Potassium Channels Pathway. Molecules, 2013, 18(4), 4209-4220 (IF 2013 = 2.095; JCR Q3; Chemistry; Organic)

24. Yu Zhao Lee*, Lee Ming-Tatt*, Nordin Hj Lajis, Mohd Roslan Sulaiman, Daud Ahmad Israf, Chau Ling Tham (2012). Development and Validation of a Bioanalytical Method for Quantification of 2,6-Bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) in Rat Plasma. Molecules, 2012, 17, 14555-14564. *Equal contribution (IF 2012 = 2.428 JCR Q2; Chemistry; Organic)

25. Lee Ming-Tatt, Shaik Ibrahim Khalivulla, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Enoch Kumar Perimal, Mohamed Hanief Khalid, Ahmad Akira, Nordin Lajis, Daud Ahmad Israf, Mohd Roslan Sulaiman. Antinociceptive Activity of a Synthetic Curcuminoid Analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on Nociception-induced Models in Mice (2012). Basic & Clinical Pharmacology & Toxicology, 2012 Mar;110(3):275-82. (IF 2012 = 2.124; JCR Q3, Pharmacology & Pharmacy)

26. Enoch Kumar Perimal, Muhammad Nadeem Akhtar, Azam Shah Mohamad, Mohd Hanief Khalid, Ong Hui Ming, Syamimi Khalid, Lee Ming Tatt, Mohd Nasier Kamaldin, Zainul Amiruddin Zakaria, Daud Ahmad Israf, Nordin Lajis, Mohd Roslan Sulaiman (2011). Zerumbone-Induced Antinociception: Involvement of the L-Arginine-Nitric Oxide-cGMP-PKC-K+ATP Channel Pathways. Basic & Clinical Pharmacology & Toxicology, 2011 Mar;108(3):155-62. (IF 2011 = 2.179; JCR Q2, Pharmacology & Pharmacy)

 

Research

Research project

Grants

Collaboration

Status

Mechanistic study on therapeutic potentials of alpha-tocopherol and tocotrienol-rich palm oil extract in murine model of menopause-associated depression and anxiety

Fundamental Research Grant Scheme (FRGS, MOHE) Principle Investigato

Universiti Putra Malaysia

On-going

Establishing dysmenorrhea-associated neuropsychological phenotypes in mice and potential therapeutic effect of Polyherbal MM-15 Formulation

UCSI University Research Excellence & Innovation Grant (REIG), Principle Investigator

Universiti Putra Malaysia

On-going

Evaluation of inhibitory effect of a synthetic curcumonoid derivative on rheumatoid arthritis-induced pain and inflammatory responses

Malaysia Toray Science Foundation (MTSF), Principle Investigator

Universiti Putra Malaysia

Completed

Gingerols and Shogaols: Investigations on the role of selective phosphodiesterase 4B inhibition in the respiratory anti-inflammatory activity without central side effects

Fundamental Research Grant Scheme (FRGS, MOHE) Co-Investigator

University Malaya & KIET Group of Institutions

On-going

Evaluation of Polyherbal Formulation, MM-15 for Dual Inhibition of 5-Lipoxygenase (5-LOX)/Cyclooxygenase 2 (COX-2) and 5-LOX derivatives in the Mechanistic Pathway of Primary Dysmenorrhea

UCSI University Research Excellence & Innovation Grant (REIG), Co-Researcher

-

On-going

The inhibitory activity of Clinacanthus nutans standardised ethanolic extract on IgE-mediated mast cell activation and anaphylactic reaction

Herbal Research Grant Scheme EPP # 1 (NRGS), Co-Researcher

Universiti Putra Malaysia

Completed

Formulation and Evaluation of Enteric Coated Capsules Filled with Oral Mucoadhesive Palifermin Nanoparticles

Fundamental Research Grant Scheme (FRGS, MOHE) Co-Researcher

Universiti Teknologi MARA

Completed

Supervision:

Undergraduate students (Completed)

  • Goh Chuhn Hung (2015)