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Dr Michelle Teo Yee Mun

Lecturer | Department of Biotechnology

Academic Qualifications

PhD Science
MSc Biomedical Science
BSc (Hons) Biological Sciences

Areas of Interest
Molecular Oncology (Immunotoxins, Antibody Engineering)
Research Grants

  1. Name of grant: Malaysia Fundamental Research Grant Scheme
    Funder: Ministry of Education
    Project Title: Investigating the synergistic potential between a G12V/A mutated KRAS vaccine in combination with anti-PD-L1 checkpoint inhibitor against colorectal cancer
    Code: FRGS/1/2021/STG01/UCSI/02/1
    Duration: 3 years
    Role: Co-investigator
    Amount: RM 194,100
    Status: On-going
  2. Name of grant: Malaysia Fundamental Research Grant Scheme
    Funder: Ministry of Education
    Project Title: Investigating the potential of surface modified cyclodextrin based gold nanoparticles for cytotoxic drugs to enhance the apoptosis in cancer cell lines.
    Code: FRGS/1/2021/SKK0/UCSI/02/5
    Duration: 2 years
    Role: Co-investigator
    Amount: RM 100,108
    ​Status: On-going
  3. Name of grant: UCSI Research Excellence & Innovation Grant
    Funder: UCSI University
    Project Title: Preclinical assessment of hemi-synthesized juglone derivative for its anticancer effects on various solid tumours
    Code: REIG-FAS-2020/030
    Duration: 2 years
    Role: Principal investigator
    Amount: RM 50,000
    ​Status: On-going
  4. Name of grant: UCSI Research Excellence & Innovation Grant
    Funder: UCSI University
    Project Title: Immuno-engineering and evaluation of an orally administered mutated KRAS multivalent tandem vaccine against colorectal cancer.
    Code: REIG-FAS-2020/060
    Duration: 2 years
    Role: Co-investigator
    Amount: RM 50,000
    ​Status: On-going

 

Current Research Project

  1. Preclinical assessment of a hemisynthesized curcumin derivatives for its anticancer effects on various solid tumours
  2. In vivo prophylactic and therapeutic study of KRAS mimotope vaccine (G12V/G12A) in combination with checkpoint inhibitor and its pairing with a KRAS aptamer-based biosensor

Publications

  1. Michelle Yee Mun Teo, Jung Yin Fong, Wan Ming Lim and Lionel Lian Aun In, (2021) Current advances and trends in KRAS targeted therapies for colorectal cancer. Molecular Cancer Therapeutics. 20, 30-44; DOI 10.1158/1541-7786.MCR-21-0248.
  2. Michelle Yee Mun Teo, Jeremy Jeack Ceen Ng, Jung Yin Fong, Jung Shan Hwang, Adelene Ai Lian Song, Renee Lay Hong Lim and Lionel Lian Aun In, (2021) Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells. PeerJ, 9:e11063; DOI 10.7717/peerj.11063.
  3. Teng Jia Ng, Michelle Yee Mun Teo, Dek Shen Liew, Paul Etim Effiong, Jung Shan Hwang, Crystale Siew Ying Lim and Lionel Lian Aun In, (2019), Cytotoxic and apoptosis-inducing effects of wildtype and mutated Hydra actinoporin-like toxin 1 (HALT-1) on various cancer cell lines. PeerJ, 7:e6639; DOI 10.7717/peerj.6639.
  4. Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Sen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song and Lionel Lian Aun In, (2018), In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens. PeerJ, 6:e5056; DOI 10.7717/peerj.5056.
  5. Michelle Yee Mun Teo, Jung Shan Hwang, Adelene Ai Lian Song, Renee Lay Hong Lim and Lionel Lian Aun In, (2019) Immuno-engineering and development of anti-mKRAS G12V single-chain variable fragment (scFv) fused-mHALT-1 recombinant immunotoxins against KRAS-positive colorectal cancer cells. BMC Proceedings, 13(8), 10; DOI 10.1186/s12919-019-0169-6.

Awards and Recognitions

  1. Best Presenter Award – 4th International Conference on Molecular Biology and Biotechnology (ICMBB) 2021
  2. Finalist - The Falling Walls lab AIMST, Malaysia
  3. Best Abstract Award - Hong Kong Croucher Summer Course 2018
  4. Best Poster Award - 2nd International Conference on Molecular Biology and Biotechnology (ICMBB) 2017