Associate Professor Dr. Renee Lim Lay Hong

Dr. Renee Lim Lay Hong

Research Impact:

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Associate Professor Dr. Renee Lim Lay Hong

Associate Professor | Department of Biotechnology
 

Academic Qualifications

PhD Biochemistry & Molecular Genetics
BSc (Hons) Biology & Chemistry

Areas of Interest
Probiotics and allergy immunotherapy
Production of recombinant bioactive proteins
Professional Affiliation

Member of Malaysian Society of Molecular Biology and Biochemistry 

Research

Research Grants

  1. Name of grant: Fundamental Research Grant Scheme (FRGS)
    Funder: Ministry of Higher Education (MoHE)
    Project Title: Genotyping of candidate genes related to myopia and obesity in a cohort of secondary school students
    Code: FRGS/1/10/SG/UCSI /02/3
    Duration: 2010 - 2013
    Role: Principal investigator
    Amount: RM38,640
    Status: Completed
  2. Name of grant: Fundamental Research Grant Scheme (FRGS)
    Funder: Ministry of Higher Education (MoHE)
    Project Title: Heterologous expression and immunotherapeutic in vivo evaluation of recombinant Ara h 2.02 allergen in lactic acid bacteria. 
    Code: FRGS/2/2014/SG/UCSI /02/1
    Duration: 2014 - 2018
    Role: Principal investigator
    Amount: RM115,200
    Status: Completed
  3. Name of grant: Research Grant Scheme (RGS)
    Funder: CERVIE (UCSI)
    Project Title: Production of recombinant peanut allergen Ara h 2.02 in Escherichia coli and Lactobacillus plantarum. (Principal Investigator; CERVIE UCSI,
    Code: RGS Proj-In-FAS-005
    Duration: 2011 - 2014
    Role: Principal investigator
    Amount: RM50,000
    Status: Completed
  4. Name of grant: Research Grant Scheme (RGS)
    Funder: CERVIE (UCSI)
    Project Title: Isolation of soil actinomycetes and screening for actinomycetes with potential antimicrobial compounds against clinically significant bacterial pathogens
    Code: RGS Proj-In-FAS-010
    Duration: 2011 - 2014
    Role: Principal investigator
    Amount: RM95,000
    Status: Completed
  5. Name of grant: Pioneer Scientist Incentive Fund (PSIF)
    Funder: CERVIE (UCSI)
    Project Title: A Novel Serine Protease from Tiger Milk Mushroom: Cloning and Production of Recombinant Serine Protease in E. coli for Functional Study. 
    Code: Proj-In-FAS-042
    Duration: 2017 - 2018
    Role: Principal investigator
    Amount: RM25,000
    Status: Completed
  6. Name of grant: Pioneer Scientist Incentive Fund (PSIF)
    Funder: CERVIE (UCSI)
    Project Title: Production of a new and functional Fungal Immunomodulatory Protein from Tiger Milk Mushroom in the Pichia pastoris expression system.
    Code: Proj-in-FAS-032
    Duration: 2016 - 2018
    Role: Principal investigator
    Amount: RM25,000
    Status: Active
  7. Name of grant: Funding from Industry
    Funder: Kotra Pharma Sdn Bhd, Malaysia
    Project Title: Isolation and identification of antibiotic resistant bacteria and detection of major viruses from primary care patients with acute pharyngitis (sore throat) in the Klang Valley 
    Code: Proj-In-KOTRA-FAS-001
    Duration:2015 - 2017
    Role: Co-investigator
    Amount: RM154,000
    Status: Completed
  8. Name of grant: Sunway Healthcare SunMed Research Grant
    Funder: Sunway Healthcare
    Project Title: Association of Methotrexate Pathway Gene Polymorphisms with Methotrexate Efficacy and Toxicity in Malaysian patients of Rheumatoid Arthritis.
    Code: SRC/001/2017/FR
    Duration: 2018 - 2019
    Role: Co-investigator
    Amount: RM49,940
    Status: Active

 

Current research project

  1. Recombinant Lactococcus lactis as immune modulator for peanut allergy
  2. Bioactivity of fungal immunomodultory proteins from mushrooms
  3. Antibiotic resistance in probiotic food and throat microbiome
  4. Association of Methotrexate Pathway Gene Polymorphisms with Methotrexate Efficacy and Toxicity in Malaysian patients of Rheumatoid Arthritis.

Publications

  1. 2019. Chong Joo CHAN, Timmy Richardo and Renee Lay Hong Lim. Current Trend in Immunotherapy for Peanut Allergy. Int Rev of Immunology
  2. Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song and Lionel Lian Aun In. In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens. PeerJ 6:e5056
  3. Choo, K.Y., Kho, C., Ong, Y.Y., Thoo, Y.Y., Lim, R.L.H., Tan, C.P. and Ho, C.W. Studies on the storage stability of fermented red dragon fruit (Hylocereus polyrhizus) drink. Food Science and Biotechnology
  4. Lim, S.S., Selvaraj, A., Ng, Z.Y., Palanisamy, M., Mickymaray, S., Cheong C.H. and Lim R.L.H. Isolation of actinomycetes with antibacterial activity against multi-drug resistant bacteria. Malaysian Journal of Microbiology 14(3):292-304.
  5. Ejike Udochukwu Camillius, Bo Zhuang. Mian, Crystale Siew Ying Lim, Renee Lay Hong Lim. Antibiotics Resistance Of Commensal Throat Bacteria From Healthy Subjects. Malay. J. Biochem. Mol. Biol. 21(1).
  6. Pushparajah, V., Fatima, A, Chong, C.H., Gambule, T.Z., Chan, C.J., Ng., S.T. Tan, C.S., Fung S.Y., Lee, S.S., Tan, N.H. and Lim, R.LH (2016) Characterisation of a New Fungal Immunomodulatory protein from Tiger Milk mushroom, Lignosus rhinocerotis. Scientific Report, 6:30010.
  7. Lew, M.H., Lim, R.L.H. Expression of a codon-optimised recombinant Ara h 2.02 peanut allergen in Escherichia coli. Applied Microbiology and Biotechnology, 100(2): 661-671
  8. Aloysius T.H. Wong, Davey Y.S. Ngu, Lydia A. Dan, Amanda S.L. Ooi and Renee L.H. Lim. Detection of antibiotic resistance in probiotics of dietary supplements. Nutrition Journal, 14 (14):95
  9. Ng ZY, Veerapen MK, Hon WM & Lim RLH. Association of Leptin/Receptor and TNF- a gene variants with adolescent obesity in Malaysia. Pediatrics International 56(5):689-697.

Conferences

  1. Joint Congress of Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI) & Asia Pacific Association of Pediatric, Allergy, Respirology and Immunology (APAPARI), 11-14th Oct2018, Centara Grand & Bangkok Convention Centre, Thailand.
  2. Joint International Conference of Biotechemistry, Molecular Biology and Biotechnology (ICBMBB) Conference, 15-16 Aug 2018
  3. Women in Science Forum: Rising Among the Stars at UCSI, 10th July 2017 co-organised by Faculty of Applied Sciences UCSI University and Women in Science Malaysian Chapter.
  4. 41st Annual Conference Of The Malaysian Society For Biochemistry & Molecular Biology (MSBMB), 17-18 Aug2016.
  5. Malaysian Society of Infectious Diseases and Chemotherapy (MSIDC), Sunway Resort and Spa Hotel, KL. 28 Feb 2016.

Awards and Recognitions

  1. UCSI University Long Service Award (2018)
  2. UCSI Top Researcher Award- Honorary Mention (2015)