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Dr Ravishankar

Assistant Professor Dr Ravishankar Ram Mani

Assistant Professor

Academic Qualifications

PhD in Biomedical Genetics
MSc. in Biochemistry
BSc. in Biochemistry

Professional Bodies Membership

2005–2010, North American Association of Obesity Research (NAASO)

2013-2019, American Society for Microbiology (ASM)

Research Area

  • Pharmacogenomics, Pharmacoproteomics, Immuno Pharmacology.
  • CRISPR/Cas9 technology in genome editing. Specifically, I can design targeting and validation strategies for creation of mutant mice and other organisms (happy to work on non-model organisms), for example, a gene knockout by introducing a stop codon, an N-terminus GFP fusion, or introduction of a short mutation like a SNP or HA tag.

Publications

1. Shaw, P., Senthilnathan, R., Krishnan, S., Suresh, D., Shetty, S., Muthukaliannan, G. K., Mani, R. R., Sivanandy, P., Chandramoorthy, H., Gupta, M. M., Baxi, S., & Jayaraj, R. (2021). A Clinical Update on the Prognostic Effect of microRNA Biomarkers for Survival Outcome in Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis. Cancers, 13(17), 4369. https://doi.org/10.3390/cancers13174369

2. Jayaraj, R., Kumarasamy, C., Shetty, S. S., Ram M, R., & Shaw, P. (2020). Clinical and conceptual comments on "Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis". The Journal of infection, 81(4), 647–679. https://doi.org/10.1016/j.jinf.2020.05.011

3. Ram M, R., Teh, X., Rajakumar, T., Goh, K. L., Leow, A., Poh, B. H., Mariappan, V., Shankar, E. M., Loke, M. F., & Vadivelu, J. (2019). Polymorphisms in the host CYP2C19 gene and antibiotic-resistance attributes of Helicobacter pylori isolates influence the outcome of triple therapy. The Journal of antimicrobial chemotherapy, 74(1), 11–16. https://doi.org/10.1093/jac/dky401.

4. Ravishankar Ram, M., Goh, K. L., Leow, A. H., Poh, B. H., Loke, M. F., Harrison, R., Shankar, E. M., & Vadivelu, J. (2015). Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection. PloS one, 10(11), e0141865. https://doi.org/10.1371/journal.pone.0141865.

5. Ravishankar Ram, M., Beena, G., Ragunathan, P., & Malathi, R. (2007). Analysis of structure, function, and evolutionary origin of the ob gene product--leptin. Journal of biomolecular structure & dynamics, 25(2), 183–188. https://doi.org/10.1080/07391102.2007.10507167

 6. Barathan, M., Mohamed, R., Vadivelu, J., Chang, L. Y., Saeidi, A., Yong, Y. K., Ravishankar Ram, M., Gopal, K., Velu, V., Larsson, M., & Shankar, E. M. (2016). Peripheral loss of CD8(+) CD161(++) TCRVα7·2(+) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients. European journal of clinical investigation, 46(2), 170–180. https://doi.org/10.1111/eci.12581

7. Tan, X. C., Chua, K. H., Ravishankar Ram, M., & Kuppusamy, U. R. (2016). Monoterpenes: Novel insights into their biological effects and roles on glucose uptake and lipid metabolism in 3T3-L1 adipocytes. Food chemistry, 196, 242–250. https://doi.org/10.1016/j.foodchem.2015.09.042

8. Baskaran, A., Chua, K. H., Sabaratnam, V., Ravishankar Ram, M., & Kuppusamy, U. R. (2017). Pleurotus giganteus (Berk. Karun & Hyde), the giant oyster mushroom inhibits NO production in LPS/H2O2 stimulated RAW 264.7 cells via STAT 3 and COX-2 pathways. BMC complementary and alternative medicine, 17(1), 40. https://doi.org/10.1186/s12906-016-1546-6

9. Paravamsivam, P., Heng, C. K., Malek, S. N., Sabaratnam, V., M, R. R., & Kuppusamy, U. R. (2016). Giant Oyster Mushroom Pleurotus giganteus (Agaricomycetes) Enhances Adipocyte Differentiation and Glucose Uptake via Activation of PPARγ and Glucose Transporters 1 and 4 in 3T3-L1 Cells. International journal of medicinal mushrooms, 18(9), 821–831. https://doi.org/10.1615/IntJMedMushrooms.v18.i9.60

10. Barathan, M., Gopal, K., Mohamed, R., Ellegård, R., Saeidi, A., Vadivelu, J., Ansari, A. W., Rothan, H. A., Ravishankar Ram, M., Zandi, K., Chang, L. Y., Vignesh, R., Che, K. F., Kamarulzaman, A., Velu, V., Larsson, M., Kamarul, T., & Shankar, E. M. (2015). Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. Apoptosis: an international journal on programmed cell death, 20(4), 466–480. https://doi.org/10.1007/s10495-014-1084-y.

11. Jayaraj, R., Raymond, G., Krishnan, S., Tzou, K. S., Baxi, S., Ram, M. R., Govind, S. K., Chandramoorthy, H. C., Abu-Khzam, F. N., & Shaw, P. (2020). Clinical Theragnostic Potential of Diverse miRNA Expressions in Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers, 12(5), 1199. https://doi.org/10.3390/cancers12051199.

Journal Reviewers

2005–2010, Indian Counsel of Medical Research (ICMR) Grant Peer Review Committee

2014–Present, BMC Journal (Invited for peer Review).

2017 – 2018, Cellular Physiology and Biochemistry Journal (Invited for peer Review).

2018 – PLoS ONE (Invited for peer Review).

2020 - Present, World Journal of Surgical Oncology (Invited for peer Review)

2020 – Present, Journal of Gynecology and Women Healthcare (JGWH) (Invited for peer Review)

Awards and Recognitions

• Indian Council of Medical Research, Junior & Senior Research Fellowship Grant – A study towards molecular screening in women with PCOD from Chennai base population – Estimation of ob protein (Serum Leptin) obmRNA expression in obese subjects; Role: Junior Research Fellow & Senior Research Fellow; Year: 23.02.2004 to 22.02.2006 (Supervisor: Malathi Raghunathan); Field of Research: Biomedical Sciences; Source of Funding: ICMR, Ministry of Human Resources, Government of India, New Delhi (Award No. 45/9/03/JRF/SRF 2004– BMS, 07/01/04).

Other achievements (examples shown below)

  • External examiner (dissertation)
  • External international grant reviewer