
Assistant Professor Dr Ravishankar Ram Mani
Assistant Professor
Academic Qualifications
PhD in Biomedical Genetics
MSc. in Biochemistry
BSc. in Biochemistry
2005–2010, North American Association of Obesity Research (NAASO)
2013-2019, American Society for Microbiology (ASM)
- Pharmacogenomics, Pharmacoproteomics, Immuno Pharmacology.
- CRISPR/Cas9 technology in genome editing. Specifically, I can design targeting and validation strategies for creation of mutant mice and other organisms (happy to work on non-model organisms), for example, a gene knockout by introducing a stop codon, an N-terminus GFP fusion, or introduction of a short mutation like a SNP or HA tag.
1. Shaw, P., Senthilnathan, R., Krishnan, S., Suresh, D., Shetty, S., Muthukaliannan, G. K., Mani, R. R., Sivanandy, P., Chandramoorthy, H., Gupta, M. M., Baxi, S., & Jayaraj, R. (2021). A Clinical Update on the Prognostic Effect of microRNA Biomarkers for Survival Outcome in Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis. Cancers, 13(17), 4369. https://doi.org/10.3390/cancers13174369
2. Jayaraj, R., Kumarasamy, C., Shetty, S. S., Ram M, R., & Shaw, P. (2020). Clinical and conceptual comments on "Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis". The Journal of infection, 81(4), 647–679. https://doi.org/10.1016/j.jinf.2020.05.011
3. Ram M, R., Teh, X., Rajakumar, T., Goh, K. L., Leow, A., Poh, B. H., Mariappan, V., Shankar, E. M., Loke, M. F., & Vadivelu, J. (2019). Polymorphisms in the host CYP2C19 gene and antibiotic-resistance attributes of Helicobacter pylori isolates influence the outcome of triple therapy. The Journal of antimicrobial chemotherapy, 74(1), 11–16. https://doi.org/10.1093/jac/dky401.
4. Ravishankar Ram, M., Goh, K. L., Leow, A. H., Poh, B. H., Loke, M. F., Harrison, R., Shankar, E. M., & Vadivelu, J. (2015). Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection. PloS one, 10(11), e0141865. https://doi.org/10.1371/journal.pone.0141865.
5. Ravishankar Ram, M., Beena, G., Ragunathan, P., & Malathi, R. (2007). Analysis of structure, function, and evolutionary origin of the ob gene product--leptin. Journal of biomolecular structure & dynamics, 25(2), 183–188. https://doi.org/10.1080/07391102.2007.10507167
6. Barathan, M., Mohamed, R., Vadivelu, J., Chang, L. Y., Saeidi, A., Yong, Y. K., Ravishankar Ram, M., Gopal, K., Velu, V., Larsson, M., & Shankar, E. M. (2016). Peripheral loss of CD8(+) CD161(++) TCRVα7·2(+) mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients. European journal of clinical investigation, 46(2), 170–180. https://doi.org/10.1111/eci.12581
7. Tan, X. C., Chua, K. H., Ravishankar Ram, M., & Kuppusamy, U. R. (2016). Monoterpenes: Novel insights into their biological effects and roles on glucose uptake and lipid metabolism in 3T3-L1 adipocytes. Food chemistry, 196, 242–250. https://doi.org/10.1016/j.foodchem.2015.09.042
8. Baskaran, A., Chua, K. H., Sabaratnam, V., Ravishankar Ram, M., & Kuppusamy, U. R. (2017). Pleurotus giganteus (Berk. Karun & Hyde), the giant oyster mushroom inhibits NO production in LPS/H2O2 stimulated RAW 264.7 cells via STAT 3 and COX-2 pathways. BMC complementary and alternative medicine, 17(1), 40. https://doi.org/10.1186/s12906-016-1546-6
9. Paravamsivam, P., Heng, C. K., Malek, S. N., Sabaratnam, V., M, R. R., & Kuppusamy, U. R. (2016). Giant Oyster Mushroom Pleurotus giganteus (Agaricomycetes) Enhances Adipocyte Differentiation and Glucose Uptake via Activation of PPARγ and Glucose Transporters 1 and 4 in 3T3-L1 Cells. International journal of medicinal mushrooms, 18(9), 821–831. https://doi.org/10.1615/IntJMedMushrooms.v18.i9.60
10. Barathan, M., Gopal, K., Mohamed, R., Ellegård, R., Saeidi, A., Vadivelu, J., Ansari, A. W., Rothan, H. A., Ravishankar Ram, M., Zandi, K., Chang, L. Y., Vignesh, R., Che, K. F., Kamarulzaman, A., Velu, V., Larsson, M., Kamarul, T., & Shankar, E. M. (2015). Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. Apoptosis: an international journal on programmed cell death, 20(4), 466–480. https://doi.org/10.1007/s10495-014-1084-y.
11. Jayaraj, R., Raymond, G., Krishnan, S., Tzou, K. S., Baxi, S., Ram, M. R., Govind, S. K., Chandramoorthy, H. C., Abu-Khzam, F. N., & Shaw, P. (2020). Clinical Theragnostic Potential of Diverse miRNA Expressions in Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers, 12(5), 1199. https://doi.org/10.3390/cancers12051199.
2005–2010, Indian Counsel of Medical Research (ICMR) Grant Peer Review Committee
2014–Present, BMC Journal (Invited for peer Review).
2017 – 2018, Cellular Physiology and Biochemistry Journal (Invited for peer Review).
2018 – PLoS ONE (Invited for peer Review).
2020 - Present, World Journal of Surgical Oncology (Invited for peer Review)
2020 – Present, Journal of Gynecology and Women Healthcare (JGWH) (Invited for peer Review)
• Indian Council of Medical Research, Junior & Senior Research Fellowship Grant – A study towards molecular screening in women with PCOD from Chennai base population – Estimation of ob protein (Serum Leptin) obmRNA expression in obese subjects; Role: Junior Research Fellow & Senior Research Fellow; Year: 23.02.2004 to 22.02.2006 (Supervisor: Malathi Raghunathan); Field of Research: Biomedical Sciences; Source of Funding: ICMR, Ministry of Human Resources, Government of India, New Delhi (Award No. 45/9/03/JRF/SRF 2004– BMS, 07/01/04).
Other achievements (examples shown below)
- External examiner (dissertation)
- External international grant reviewer