VIRTUAL TOUR
Associate Professor Dr Mai Chun Wai
Head of Department, Pharmaceutical Chemistry
Academic Qualifications
Chartered Scientist, Royal Society of Chemistry, United Kingdom, 2019
Doctor of Philosophy in Medical and Health Sciences, International Medical University, Malaysia, 2010-2014
Certified Good Clinical Practice (GCP), Ministry of Health, Malaysia, 2012
Bachelor of Pharmacy (Hons.), International Medical University, Malaysia, 2005-2009
Areas of Interest
- International Pharmaceutical Federation, Netherlands
- European Association for Cancer Research, Europe
- Royal Society of Chemistry, United Kingdom
- Chinese Society for Cell Biology, China
- Malaysian Association of Cancer Research, Malaysia
- Young Scientist Network-Academy of Sciences, Malaysia
- Academy of Pharmacy, Malaysia
- Malaysian Pharmacists Society, Malaysia
| Current research project (PI/Co-PI) | Grants | Collaboration | Status |
|---|---|---|---|
Systematic elucidation of the roles of METRONAS (METastasis related genes in RadiOresistant NASopharyngael carcinoma) using genomic and proteomic analyses (PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | Shanghai Jiao Tong University, Institute for Medical Research, Monash University, AGTC Genomics Sdn Bhd | Ongoing |
Genomic sequencing and bioinformatic analyses to elucidate metastatic related genes in human metastatic nasopharyngeal carcinoma (PI) | UCSI University Research Excellence & Innovation Grant (REIG) | Shanghai Jiao Tong University, Institute for Medical Research, University Malaya, AGTC Genomics Sdn Bhd | Ongoing |
Conception, Synthesis and Evaluation of tricarbonylrhenium (I) complexes as potent antibacterial and/or anticancer agents (Co-PI) | France-Malaysia Collaboration Programme for Joint Research (MyTiger) | Universite of Toulouse III, Monash University, International Medical University | Ongoing |
Combinatorial Effect of Carotenoids and Tocotrienols in Age-Related Macular Degeneration | Malaysia Palm Oil Board (MPOB) | Malaysia Palm Oil Board (MPOB) | Ongoing |
Delineating protein kinase pathways mediating immune resistance in pancreatic cancer (Co-PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | International Medical University, Sunway University, Monash University, AGTC Genomics Sdn Bhd | Ongoing |
Functional role of high LC3b-expressing luminal progenitors in prostate regeneration, and the initiation and progression of AR-independent prostate cancer (Co-PI) | National Natural Science Foundation for China, China | Shanghai Jiao Tong University affiliated Renji Hospital (China) | Ongoing |
Identification of effective drugs targeting pancreatic cancer cells with acquired resistance towards CD8+ T cell mediated cytotoxicity (Co-PI) | Malaysia Toray Science Foundation, Malaysia | International Medical University | Ongoing |
Artificial intelligence for digital pathology: Machine intelligence for cancer pathology, detection and diagnosis (Co-PI) | Ministry of Higher Education, Konsortium Kecemerlangan Penyelidikan (KKP), Malaysia | Multimedia University, International Medical University, Universiti Kebangsaan Malaysia | Ongoing |
Deconvoluting the molecular mechanisms of kinase inhibitor induced cardiotoxicity (Co-PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | International Medical University, University of Strathclyde (UK), International Agency for Research on Cancer (France) | Ongoing |
Role of superhydrophobic surface to alleviate hemolysis and biofilm formation for blood containing medical devices | Fundamental Research Grant Scheme (FRGS), Malaysia | International Medical University, Universiti Putra Malaysia | Ongoing |
Role of LY6D positive prostate cancer cells in tumor progression and androgen deprivation therapy failure. (PI) | Foreign Youth Talent Programme by the Shanghai Municipal Science and Technology Commission, China | Shanghai Jiao Tong University affiliated Renji Hospital (China) | Completed |
Elucidating the functional role of sphingosine kinase 1 (SPHK1) in mediating breast cancer stem cell survival through interferon (IFN)/STAT1 signaling pathway (Co-PI) | National Cancer Council Malaysia (MAKNA), Malaysia | International Medical University | Completed |
Regulation of nasopharygeal cancer cells (NPC) survival by p38 mitogen activated protein kinase (MAPK) (Co-PI)
| MyPAIR-PHC-Hibiscus, Malaysia | International Medical University, International Agency for Research on Cancer (France), Universiti Kebangsaan Malaysia, Institute Medical Research | Completed |
Molecular evaluation of biogeography and functional redundancy theory in Antarctic rhizosphere prokaryotic communities (PI) | Yayasan Penyelidikan Antartika Sultan Mizan (YPASM) | International Medical University, Monash University, Sarawak Research and Development Council, Universiti Malaya, British Antarctic Survey (UK), University of Northumbria (UK), Universiad Mayor (Chile). | Completed |
Preparation, characterization and anticancer effects of gemcitabine-tocotrienols entrapped niosomes in pancreatic cancer (PI)
| Malaysia Palm Oil Board (MPOB), Malaysia | International Medical University, Malaysia Palm Oil Board (MPOB) | Completed |
Mechanistic basis of tumor evasion from cytotoxic T cell (CTL) surveillance in pancreatic cancers (PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | Cambridge University (UK), International Medical University, Universiti Putra Malaysia, Univeristi Malaya, Malaysia Genomic Resource Centre Sdn Bhd. | Completed |
The antifungal effects of bacteria isolated from Antarctic soil (PI) | Yayasan Penyelidikan Antartika Sultan Mizan (YPASM) | International Medical University, British Antarctic Survey (UK) | Completed |
Study of bioactive compounds in bacteria isolated from Antarctic soil. (PI) | Yayasan Penyelidikan Antartika Sultan Mizan (YPASM) | International Medical University, British Antarctic Survey (UK), National Research Council (Italy) | Completed |
Effect of palm carotene mix on molecular targets implicated in human disease: a high throughput screening approach (Co-PI) | Malaysia Palm Oil Board (MPOB), Malaysia | International Medical University, Malaysia Palm Oil Board (MPOB) | Completed |
Chemical profiling, dereplication and isolation of new and cytotoxic chemical constituents from Goniothalamus lanceolatus (Ban) Mat-salleh (Co-PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | International Medical University, Universiti Teknologi MARA, Universiti Malaya, University Malaysia Sabah | Completed |
Functional roles of sphingosine kinase 1 (SPHK1) in human breast cancer stem cells (Co-PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | International Medical University, University of Strathclyde (UK) | Completed |
System biology comparison between mice with single and co-infection from Toxoplasma gondii and/or Trypanosoma evansi (Co-PI) | Fundamental Research Grant Scheme (FRGS), Malaysia | International Medical University, Universiti Teknologi MARA | Completed |
Synthesis, biological evaluation and structure activity relationship studies on shogaol analogues as new class of compounds targeting Peroxisome Proliferator-Activated Receptor gamma (PI) | Malaysia Toray Science Foundation, Malaysia | International Medical University | Completed |
Supervision: (Current student on top, followed by completed. Example shown below)
PhD students (Current)
- Zhao Wen Yang, Doctor of Philosophy (Pharmaceutical Sciences), UCSI University
Master students (Current)
- Tan Pei Yi, Master of Science in Pharmaceutical Chemistry, UCSI University
- Loo Ee Mun, Master of Science (Pharmaceutical Sciences), UCSI University
- Zhou Ting, Master in Applied Sciences by Research, UCSI University
Master students (Completed)
- Han Rui, Master of Science in Pharmaceutical Chemistry, UCSI University
Provisional registered pharmacist (Current)
- Evelyn Lau Xiao Xin, UCSI University
- Gan Min Huei, UCSI University
(95) Kok-Lun Pang, Chun-Wai Mai, Kok-Yong Chin. Molecular Mechanism of Tocotrienol mediated anticancer properties: a systematic review of the involvement of endoplasmic reticulum stress and unfolded protein response Nutrients 2023, 15 (8), 1854
(94) Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai. Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer. Cell Biology and Toxicology 2023. 39: 2501-26
(93) Sangeetha Shyam, Darren C Greenwood, Chun-Wai Mai, Seok Shin Tan, Barakatun-Nisak Mohd Yusof, Foong Ming Moy, Janet E. Cade. Major dietary patterns in the United Kingdom Women’s Cohort Study showed no evidence of prospective association with pancreatic cancer risk. Nutrition Research 2023; 118:41-51.
(92) Sophia Ogechi Ekeuku, Effiong Paul Etim, Kok-Lun Pang, Kok-Yong Chin, Chun-Wai Mai. Vitamin E in the management of pancreatic cancer: A scoping review. World Journal of Gastrointestinal Oncology 2023; 15(6): 943-958
(91) Xun Hui Wu, Yun Khoon Liew, Wei Meng Lim, Chun-Wai Mai, Yoon Yee Then. Blood compatible and noncytotoxic superhydrophobic graphene/titanium dioxide coating with antibacterial and antibiofilm properties. Journal of Applied Polymer Science 2023; doi: 10.1002/app.53629
(90) Jeonghun Baek, Chun Wai Mai, Wei Meng Lim, Lai Chun Wong. Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells. International Journal of Ophthalmology 2023;16(1):40-46,doi:10.18240/ijo.2023.01.06
(89) Han Rui, Anand Gaurav, Chun-Wai Mai, Vertika Gautam, Gabriel Akyirem Akowuah. Phosphodiesterase Inhibitors of Natural Origin. The Natural Products Journal 2023.
(88) Chun-Wai Mai, Kok-Yong Chin, Lian-Chee Foong, Kok-Lun Pang, Bin Yu, Yu Shu, Sisi Chen, Soon-Keng Cheong, Chee-Wai Chua. Modeling prostate cancer: what does it take to build an ideal tumor model? Cancer Letters 2022; 543: 215794
(87) Chin-King Looi, Li-Lian Gan, Wynne Sim, Ling-Wei Hii, Felicia Fei-Lei Chung, Chee-Onn Leong, Wei-Meng Lim, Chun-Wai Mai. Histone deacetylase inhibitors restore cancer cell sensitivity towards T lymphocytes-mediated cytotoxicity in pancreatic cancer. Cancers 2022; 14(15):3709. doi: 10.3390/cancers14153709.
(86) Wynne Sim, Wei-Meng Lim, Ling-Wei Hii, Chee-Onn Leong, Chun-Wai Mai. Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases World Journal of Gastroenterology 2022; 28(18):1934-1945.
(85) Lesley Jia Wei Pua, Felicia Fei-Lei Chung, Chun-Wai Mai, Alan Soo-Beng Khoo, Chee-Onn Leong, Wei-Meng Lim, Ling-Wei Hii. Functional Roles of JNK and p38 MAPK signaling in Nasopharyngeal Carcinoma. International Journal of Molecular Science 2022; 23(3):1108
(84) Hui Shan Liew, Chun-Wai Mai, Mohd Zulkefeli, Thiagarajan Madheswaran, Lik Voon Kiew, Lesley Pua Jia Wei, Ling Wei Hii, Wei Meng Lim, May Lee Low Novel gemcitabine-Re(I) bisquinolinyl complex combinations and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy. Frontiers in Pharmacology 2022; 13:903210. doi: 10.3389/fphar.2022.903210.
(83) Eun-Seon Cho, Premanand Krishnan, Hwei-San Loh, Janet M Daly, Chee-Onn Leong, Chun-Wai Mai, Yun-Yee Low, Kien-Thai Yong, Kuan-Hon Lim. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus. Phytochemistry 2022; 193: 112988
(82) Yong Zhang, Xian-Li Song, Bin Yu, Lian-Chee Foong, Yu Shu, Chun-Wai Mai, Jing Hu, Baijun Dong, Wei Xue, Chee Wai Chua. TP53 loss-of-function causes vulnerability to autophagy inhibition in aggressive prostate cancer. International Journal of Urology 2022; 29(9), 1085-94
(81) Himshikha Sharma, Shweta Chaudhary, Sonam Nirwan, Rita Kakkhar, Hui-Shan Liew, May-Lee Low, Chun-Wai Mai, Ling-Wei Hii, Chee-Onn Leong, Marilyn Daisy Milton. N, N’-Disubstituted Benzimidazolium Salts: Synthesis,Characterization, Micromolar Detection of Fe(III) ions in Aqueous system, Biological Evaluation and Molecular Docking Studies. ChemistrySelect 2022; 7(48), e202203239
(80) Puvaneswari Meganathan, Chun-Wai Mai, Kanga Rani Selvaduray, Zaida Zainal, Ju-Yen Fu. Effect of Carotenes against Oxidative Stress Induced Age-Related Macular Degeneration in Human Retinal Pigment Cells. ACS Food Science & Technology 2022; 2(11), 1719-27
(79) Kitson Liew, Gibson Yu Sheng Qi, Lesley Jia Wei Pua, Li Zhe Wong, Shiau Ying Tham, Ling-Wei Hii, Wei-Meng Lim, Brian Ming OuYong, Chin King Looi, Chun-Wai Mai, Felicia Fei-Lei Chung, Lu Ping Tan, Munirah Ahmad, Alan Soo-Beng Khoo, Chee Onn Leong. Parallel genome-wide RNAi screens identifies lymphocyte-specific protein tyrosine kinase (LCK) as a key regulator of cell proliferation and chemoresistance in nasopharyngeal carcinoma. Cancer Letters 2021; 504: 81-90
(78) Chin-King Looi, Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Wei-Meng Lim, Chee-Onn Leong. Roles of inflammasomes in Epstein-barr virus associated nasopharyngeal cancer. Cancers 2021; 13(8), 1786
(77) Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei-Yuen Ng, Chee-Onn Leong. Sphingosine kinase 1 (SPHK1) signaling in breast cancer: a potential target to tackle breast cancer stem cells. Frontiers in Molecular Biosciences 2021; 8:748470.
(76) Sangeetha Shyam, Darren Greenwood, Chun-Wai Mai, Seok-Shin Tan, Barakatun Nisak Mohd Yusof, Foong Ming Moy, Janet Cade. Traditional and novel adiposity indicators and pancreatic cancer risk: findings from the UK Women’s Cohort Study. Cancers 2021; 13(5): 1036.
(75) Xun Hui Wu, Yun Khoon Liew, Chun Wai Mai, Yoon Yee Then. Potential of superhydrophobic surface for blood-contacting medical devices.International Journal of Molecular Sciences, 2021; 22(7): 3341
(74) Geetha Nalairndran, Ivy Chung, Azad Hassan Abdul Razack, Felicia Fei‐Lei Chung, Ling‐Wei Hii, Wei‐Meng Lim, Chin King Looi, Chun‐Wai Mai, Chee‐Onn Leong. Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells. Journal of Cellular and Molecular Medicine 2021; 25(17): 8187-8200
(73) Geetha Maniam, Chun-Wai Mai, Mohd Zulkefeli, Ju-Yen Fu. Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer Nanomedicine 2021; 16(5): 373-89
(72) Chan, Zi-Yang; Krishnan, Premanand; Modaresi, Sayed Mohammadhossein; Hii, Ling-Wei; Chun-Wai Mai; Lim, Wei-Meng; Leong, Chee Onn; Low, Yun-Yee; Wong, Soon-Kit; Thai, Yong-Kien; Leong, Alyssa; Lee, Mei-Kee; Ting, Kang-Nee; Lim, Kuan-Hon. Monomeric, Dimeric and Trimeric Tropane Alkaloids from Pellacalyx saccardianus. Journal of Natural Products 2021; 84(8):2272-2281. doi: 10.1021/acs.jnatprod.1c00374.
(71) Annamarie Jacob Thomas, June Pui Yin Lee, Siew Kheong Lum, Noor Hasni Shamsudin, Ling Wei Hii, Chun-Wai Mai, Shew Fung Wong, Chee Onn Leong. Gene expression profiling of giant fibroadenomas of the breast. Surgical Oncology 2021; 37, 101536.
(70) Hui Yin Yow, John Jeh Lung Tiong, Chun Wai Mai, Esther van der Werf, Zulkifli Md Zainuddin, Charng Chee Toh, Kay Seong Ngoo, Eng Hong Goh, Ahmad Nazran Fadzli, Sze Han Lok, Teng Aik Ong. Prevalence of nocturia among community-dwelling adults: A population based study in Malaysia. BMC Urology 2021; 21(1):95. doi: 10.1186/s12894-021-00860-1.
(69) Zi-Yang Chan, Premanand Krishnan, Ling Wei Hii, Chun Wai Mai, Chee Onn Leong, Yun Yee Low, Soon Kit Wong, Kang Nee Ting, Kien Thai Yong, Kuan Hon Lim. Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus Phytochemistry Letters 2021; 46: 36-44
(68) Chun-Wai Mai, Yu Shu, Soon-Keng Cheong, Chee Wai Chua. Prostate organoid technology – the new POT of gold in prostate stem cell and cancer research. Acta Physiologica Sinica 2021; 73(2):181-196.
(67) Krishnaraj Padmavathy, Kannan Gokula Krishnan, Chandran Udhaya Kumar, Vadivel Saravanan, Wei-Meng Lim, Chun-Wai Mai, Chennan Ramalingan. Novel Phenothiazinyl Acrylonitrile Hybrids: Synthesis, Biological, and Density Functional Theory Studies. Indian Journal of Heterocyclic Chemistry. 2021; 31(2): 301-11
(66) Li-Lian Gan; Ling-Wei Hii; Shew-Fung Wong; Chee-Onn Leong; Chun-Wai Mai. Molecular Mechanisms and Potential Therapeutics Reversal of Pancreatic Cancer-Induced Immune Evasion Cancers 2020; 12(7), 1872
(65) Chin-King Looi, Ling-Wei Hii, Siew Ching Ngai, Chee-Onn Leong, Chun-Wai Mai. The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player? Biomedicines 2020; 8(9), 334
(64) Naing Cho, Chee Onn Leong, Htar Htar Aung, Chun-Wai Mai, Elaine Wan Ling Chan, Siang Tong Kew. Gene therapy for people with hepatocellular carcinoma .Cochrane Database of Systematic Reviews 2020; 9. DOI: 10.1002/14651858.CD013731.
(63) Geetha Nalairndran, Azad Hassan Abdul Razack, Chun-Wai Mai, Felicia Fei-Lei Chung, Kok-Keong Chan, Ling-Wei Hii, Wei-Meng Lim, Ivy Chung, Chee-Onn Leong. Phosphoinositide-Dependent Kinase-1 (PDPK1) Regulates Serum/Glucocorticoid Regulated Kinase 3 (SGK3) for Prostate Cancer Cells Survival. Journal of Cellular and Molecular Medicine 2020; 24(20): 12188-98
(62) Ling-Wei Hii; Felicia Fei-Lei Chung; Chun-Wai Mai; Zong-Yang Yee, Hong-Hao Chan, Vijay Jospeh Raja, Noah Elias Dephoure, Nigel J Pyne, Susan Pyne, Chee-Onn Leong. Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1. Cells 2020; 9(4), 886
(61) Ling-Wei Hii; Felicia Fei-Lei Chung; Jaslyn Sian-Siu Soo; Boon Shing Tan; Chun-Wai Mai; Chee-Onn Leong. Histone Deacetylase (HDAC) Inhibitors and Doxorubicin Combinations Target Both Breast Cancer Stem Cells and Non-Stem Breast Cancer Cells Simultaneously.Breast Cancer Research and Treatment. 2020 Feb;179(3):615-629
(60) Alan Cheuk Keong Yaw, Elaine Wan Ling Chan, Jeremy Kean Yi Yap, Chun Wai Mai. The Effects of NLRP3 Inflammasome Inhibition by MCC950 on LPS-induced Pancreatic Adenocarcinoma Inflammation. Journal of Cancer Research and Clinical Oncology. 2020, 146,2219–2229
(59) Ramalingan Chennan, Shumugan Iniyaval, Wei-Meng Lim, Ling-Wei Hii, Chun-Wai Mai, Chennan Ramalingan. Pyrazolylphenanthroimidazole heterocycles: Synthesis, biological and molecular docking studies. New Journal of Chemistry. 2020, doi.org/10.1039/D0NJ02214D
(58) Ramalingan Chennan, Sivaramakarthikeyan, Ayyanar Karuppasamy, Shumugan Iniyaval, Krishnaraj Padmavathy, Wei-Meng Lim, Chun-Wai Mai, Chennan Ramalingan. Phenothiazine and amide ornamented novel nitrogen heterocyclic hybrids: Synthesis and their biological and molecular docking studies. New Journal of Chemistry. 2020, doi:10.1039/C9NJ05498H
(57) Hui Shan Liew, Chun-Wai Mai, Mohd Zulkefeli, Thiagarajan Madheswaran, Lik Voon Kiew, Nicolas Delsuc, May Lee Low. Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy. Molecules. 2020, 25(18), 4176
(56) Ramar Sivaramakarthikeyan, Shunmugam Iniyaval, Vadivel Saravanan, Wei-Meng Lim, Chun-Wai Mai, Chennan Ramalingan. Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies. ACS Omega. 2020; 5(17): 10089-98, doi: 10.1021/acsomega.0c00630
(55) Lucy Chappel, Lai Chun Wong, Chee-Onn Leong, Chun-Wai Mai, Ian T. Meikle, Stephen P. Stanforth,Thang V. Truong. The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters 2020; 30 (4), 126910
(54) Kannan Gokula Krishnan, Chandran Udhaya Kumar, Wei-Meng Lim, Chun-Wai Mai, Punniyakoti V.Thanikachalam, ChennanRamalingan. Novel cyanoacetamide integrated phenothiazines: Synthesis, characterization, computational studies and in vitro antioxidant and anticancer evaluations. Journal of Molecular Structure. 2020; 1199: 127037
(53) Shun-Kai Yang, Teik-Kee Leo, Chun-Wai Mai, Swee-Yee Chin, Dhilia Udie Lamsudin, Swee-Hua Erin Lim, Ngai-Paing Tan, Kok-Song Lai. Protein expression patterns in HEK-Blue cells treated with Clinacanthus nutans extracts. Pharmacognosy Magazine 2020; 16(70): 431-434.
(52) Chun-Wai Mai, Jennifer See Hui Tan, Gina Wan Lee Koay, Lucas Yang Xian Lim. Integrative Nutrition CARE in the Community – Starting with Pharmacists. Pharmacy 2020, 8(3), 170
(51) Sheba R David, Nurul Akmar binti Anwar, Koh Rhun Yian, Chun-Wai Mai, Sanjoy Kumar Das, Rajan Rajabalaya. Development and evaluation of curcumin liquid crystal systems for cervical cancer. Scientia Pharmaceutica. 2020; 88,15; doi:10.3390/scipharm88010015
(50) Maitha Ahmed Almakhmari, Shaima Ibrahim Alameri, Swee-Yee Chin, Chun-Wai Mai, Kok-Song Lai and Swee-Hua Erin Lim. Antibacterial Activity of Clinacanthus nutans Polar and Non-Polar Leaves and Stem Extracts.Biomedical and Pharmacology Journal. 2020;13(3).
(49) Loo Jason, Lo Eva, Chun Wai Mai, Pou Wee Gan, E Lyn Lee, John Tiong. Separation of Prescribing and Dispensing in Malaysia: Disparity between Public Perception of the Benefit and Country’s Readiness to Implement a Separation Policy. Journal of Pharmacy Practice and Research. 2020. 50(1): 5-12
(48) Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli, Chun-Wai Mai. Therapeutic Challenges and Current Immunomodulatory Strategies in Targeting the Immunosuppressive Pancreatic Tumor Microenvironment. Journal of Experimental & Clinical Cancer Research. 2019; 38:162
(47) Ling-Wei Hii. Swee-Hua Erin Lim, Chee-Onn Leong, Swee-Yee Chin, Ngai-Paing Tan, Kok-Song Lai, Chun-Wai Mai. The Synergism of Clinacanthus nutans Lindau Extracts with Gemcitabine: Downregulation of Anti-apoptotic Markers in Squamous Pancreatic Ductal Adenocarcinoma. BMC Complementary and Alternative Medicine. 2019 Sep 14;19(1):257. doi: 10.1186/s12906-019-2663-9.
(46) Shiau-Ying Tham, Hwei-San Loh, Chun-Wai Mai, Ju-Yen Fu. Tocotrienols Modulate a Life or Death Decision in Cancers. International Journal of Molecular Sciences. 2019; 20(2): 372
(45) Yuan-Seng Wu, Zhong Yang Lee, Lay-Hong Chuah, Chun-Wai Mai, Siew-Ching Ngai. Epigenetics in Metastatic Breast Cancer: Its Regulation and Implications in Diagnosis, Prognosis and Therapeutics.Current Cancer Drug Targets. 2019; 19(2): 82-100
(44) Nur Vicky Bihud, Nurulfazlina Edayah Rasol, Syahrul Imran Abu Bakar, Khalijah Awang, Fasihuddin Badruddin Ahmad, Chun-Wai Mai, Chee-Onn Leong, Geoffrey A. Cordell, Nor Hadiani Ismail. Goniolanceolatins A-H, Cytotoxic Bis-styryllactones from Goniothalamus lanceolatus Miq. Journal of Natural Products. 2019 Sep 27;82(9):2430-2442.
(43) Gokulakrishnan Kannan, Pathinettampadi Ashothai, Padmavathy Krishnaraj, Wei-Meng Lim, Chun-Wai Mai, Punniyakoti V Thanikachalam, Ramalingan Chennan. Hydrazide integrated carbazoles: synthesis, computational, anticancer and molecular docking studies. New Journal of Chemistry. 2019. doi: 10.1039/C9NJ01912J
(42) Krishnaraj Padmavathy, Kannan Gokula Krishnan, Chandran Udhaya Kumar, Ethiraj Sathiyaraj, Ramar Sivaramakarthikeyan, Wei-Meng Lim, Chun-Wai Mai and Chennan Ramalingan. Novel acrylamide / acrylonitrile tethered carbazoles: synthesis, structural, biological and density functional theory studies. New Journal of Chemistry 2019, doi 10.1039/C9NJ02170A.
(41) Sivaramakarthikeyan Ramar, Iniyaval Shunmugam, Padmavathy Krishnaraj, Hui-Shan Liew, Chin-King Looi, Chun-Wai Mai, Ramalingan Chennan. Phenothiazine and amide ornamented dihydropyridines via molecular hybridization approach: Design, synthesis, biological evaluation and molecular docking studies. New Journal of Chemistry. 2019. doi: 10.1039/C9NJ01912J
(40) Dedrick Soon Seng Song, Sze Wei Leong, Kwok Wen Ng, Faridah Abas, Khozirah Shaari, Chee-Onn Leong, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei-Jean Tan. Novel 2-benzoyl-6-(2,3-dimethoxybenzylidene)-cyclohexenol confers selectivity towards human MLH1 defective cancer cells through synthetic lethality. SLAS Discovery. 2019; 24(5): 548-62
(39) Premanad Krishnan, Chun-Wai Mai, Kien-Thai Yong, Yun-Yee Low, Kuan-Hon Lim. Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris. Tetrahedron Letters. 2019; 11: 789-91
(38) Sudtha Murthy, Ummi Husni Aminah Mohd Hazli, Kin Weng Kong, Chun-Wai Mai, Chee-Onn Leong, Noorsaadah Abd. Rahman, Kong Mun Lo, and Chin Fei Chee. Identification Of Novel Sesamol Dimers With Unusual Methylenedioxy Ring-Opening Skeleton And Evaluation Of Their Antioxidant And Cytotoxic Activities. Current Organic Synthesis. 2019, 16(8), doi: 10.2174/1570179416666191003095253
(37) Tanisha Sachdeva, May Lee Low, Chun-Wai Mai, Siew Lee Cheong, Yun Khoon Liew, Marilyn Daisy Milton. Design, synthesis and characterisation of novel phenothiazine based triazolopyridine derivatives: Evaluation of anti-breast cancer activity on human breast carcinoma. ChemistrySelect. 2019 , doi.org/10.1002/slct.201903203
(36) Chan Kiang Lim, Shu Ying Gan, Vivien Yi, Mian Jong, Chee Onn Leong, Chun-Wai Mai, Chin Fei Chee. Cytotoxic activity of phytochemicals from the stem bark of Calophyllum castaneum. Pakistan Journal of Pharmaceutical Sciences 2019, 32 (5): 2183-7
(35) Chun-Wai Mai, E-Lyn Lee, Pei-Se Wong, Hui-Meng Er. Evaluation of Computer-based Simulation Learning on Knowledge, Learning Approaches and Motivation among Pharmacy Students. Indian Journal of Pharmaceutical Education and Research. 2019; 53(4):595-602
(34) Wei Yang Kong, Zong Yang Yee, Chun-Wai Mai, Chee Mun Fang, Syahril Abdullah, Siew Ching Ngai. Zebularine and trichostatin sensitized human breast adenocarcinoma cells towards tumor necrosis factor-related apoptosis inducing ligand (TRAIL) induced apoptosis. Heliyon 2019, 5(9), e02468
(33) Sheba R David, Syahira Abdul Refai, Rhun Yian Koh, Chun-Wai Mai, Sanjoy Kumar Das, Rajan Rajabalaya. Development and evaluation of liquid crystal systems of combination of 5-fluorouracil and curcumin for cervical cancer cell line. Journal of Pharmacy & Pharmacognosy Research 2019; 7(6): 441-453
(32) Zin Quat Tan, Hui Yin Leow, David Weerasingam, Kanakeswary Karisnan, Chun Wai Mai, Adelene Ai Lian Song, Wai Sum Yap, Erin Lim, Kok Song Lai. Co-culture systems for the production of secondary metabolites: Current and future prospects. The Open Biotechnology Journal. 2019; 13: 18-26
(31) Chun Wai Mai, Yew Beng Kang, Ahmad Sazali Hamzah, Mallikarjuna Rao Pichika. Comparative efficacy of vanilloids in inhibiting toll-like receptor-4 (TLR-4)/myeloid differentiation factor (MD-2) homodimerisation. Food & Function. 2018; 9: 3344-3350
(30) Chun-Wai Mai, Yew Beng Kang, Vishna Devi Nadarajah, Ahmad Sazali Hamzah, Mallikarjuna Rao Pichika. Drug-like vanilloids induce anticancer activity by inhibiting proliferation, inducing cancer cells death and regulating of bcl-related apoptotic proteins. Phytotherapy Research. 2018; 32(6):1108-1118
(29) Premanand Krishnan, Fong-Kai Lee, Kam-Weng Chong, Chun-Wai Mai, Azira Muhamad, Siew-Huah Lim, Yun-Yee Low , Kang-Nee Ting, and Kuan-Hon Lim. Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris. Organic Letters 2018, 20 (24), 8014–8018
(28) Jia-Lin Er, Pei-Ni Goh, Chen-Yuan Lee, Ying-Jie Tan, Ling Wei Hii, Chun-Wai Mai, Felicia Fei-Lei Chung, Chee-Onn Leong. Identification of Inhibitors Synergising Gemcitabine Sensitivity in Squamous Subtype of Pancreatic Ductal Adenocarcinoma (PDAC). Apoptosis 2018, 23(5-6): 343-355
(27) Geetha Maniam, Chun Wai Mai, Mohd Zulkefeli Mat Jusoh, Christine Dufes, Doryn Meam Yee Tan, Ju Yen Fu. Challenges and opportunities of nanotechnology as delivery platform for tocotrienols in cancer therapy. Frontiers in Pharmacology. 2018; 9: 1358
(26) Rasol Nurulfazlina Edayah, Ahmad Fasihuddin Badruddin, Xiang-Yin Lim, Felicia Fei-Lei Chung, Chee-Onn Leong, Chun-Wai Mai, Bihud Nur Vicky, Zaki Hamizah Mohd, Ismail Nor Hadiani. Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq. Phytochemistry Letters. 2018; 24: 51-5.
(25) Nurulfazlina Edayah Rasol, Fasihuddin Badruddin Ahmad, Chun-Wai Mai, Nur Vicky Bihuda,Fauziah Abdullah, Khalijah Awang and Nor Hadiani Ismail. Styryl Lactones from Roots and Barks Goniothalamus lanceolatus. Natural Product Communications. 2018;13:1575-78.
(24) Shun-Kai Yang, Lee-Yoon Low, Polly Soo-Xi Yap, Khatijah Yusoff, Chun-Wai Mai, Kok-Song Lai, Swee-Hua Erin Lim. Plant-Derived Antimicrobials: Insights into Mitigation of Antimicrobial Resistance. Records of Natural Products. 2018; 12(4):295-396. ACG Publications | ISI | IF: 2.000 | Citation: 32| Tier(Q) : Q2 in Plant Science
(23) Keng Yoon Yeong, Soo Choon Tan, Chun-Wai Mai, Chee-Onn Leong, Felicia Fei-Lei Chung, Yean Kee Lee, Chin Fei Chee, Noorsaadah Abdul Rahman. Contrasting sirtuin and PARP activity of selected 2,4,6-trisubstituted benzimidazoles. Chemical Biology & Drug Design. 2018;91(1):213-219.
(22) You Sheng Chong, Chun Wai Mai, Chee Onn Leong, Lai Chun Wong. Lutein and zeaxanthin reduces cytotoxicity and Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial. Cutaneous and Ocular Toxicology 2018; 37(1):52-60.
(21) John Jeh Lung Tiong, Hui Ling Kho, Chun Wai Mai, Hui Ling Lau, Syed Shahzad Hasan. Academic dishonesty among academics in Malaysia: A comparison between healthcare and non-healthcare academics. BMC Medical Education. 2018, 18(1), 168.
(20) Hui-Qi See, Jin-Ning Chan, Shu-Jin Ling, Shang-Cheng Gan, Chee-Onn Leong, Chun-Wai Mai. Advancing Pharmacy Service using Big Data – Are We Fully Utilising the Big Data’s Potential Yet? Journal of Pharmacy and Pharmaceutical Sciences. 2018, 21(1), 217-221
(19) Shun Kai Yang, Khatijah Yusoff, Chun Wai Mai, Wei Meng Lim, Wai Sum Yap, Swee Hua Erin Lim, Kok Song Lai. Additivity vs Synergism: Investigation of the Additive Interaction of Cinnamon bark oil and Meropenem in Combinatory Therapy. Molecules. 2017;22(11)
(18) Amjad Ayad Qatran Al-Khdhairawi, Premanand Krishnan, Chun-Wai Mai, Felicia Fei-Lei Chung, Chee-On Leong, Yun-Yee Low, Toh-Seok Kam, Kien-Thai Yong, and Kuan-Hon Lim. A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis. Journal of Natural Products 2017; 80(10):2734-2740
(17) Felicia Fei-Lei Chung, Perry Tan, Vijay Joseph Raja, Boon Shing Tan, Kuan-Hon Lim, Toh-Seok Kam, Ling-Wei Hii, Si Hoey Tan, Sze-Jia See, Yuen-Fen Tan, Li Zhe Wong, Wai Keat Yam, Chun Wai Mai, Tracey D. Bradshaw, Chee-Onn Leong. Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1. Scientific Reports 2017; 7: 42504
(16) Hsien Chuen Soo, Felicia Fei-Lei Chung, Kuan-Hon Lim, Veronica Alicia Yap, Tracey D. Bradshaw, Ling-Wei Hii, Si Hoey Tan, Sze Jia See, Yuen Fen Tan, Chee-Onn Leong, Chun-Wai Mai. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-kinase (PI3K)-AKT Pathway. PLoS ONE 2017; 12(1):e0170551
(15) Chun Wai Mai, Felicia Fei-Lei Chung, Chee-Onn Leong. Targeting legumain as a novel therapeutic strategy in cancers. Current Drug Targets 2017; 18(11):1259-1268
(14) Chan Kiang Lim, Subramaniam Hemaroopini, Shu Ying Gan, Siew Mian Loo, Jo Ring Loo, Vivien Yi Mian Jong, Hsien Chuen Soo, Chee Onn Leong, Chun Wai Mai, Chin Fei Chee. In vitro cytotoxic activity of chemical constituents from Malaysia Calophyllum species. Medicinal Chemistry Research 2016; 25(8) 1686–1694
(13) Chun Wai Mai, Kok Seng Ivan Yap, Mee Teck Kho, Nor Hadiani Ismail, Khatijah Yusoff, Khozirah Shaari, Swee Yee Chin, Erin Swee Hua Lim. Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans Lindau extracts: inhibition of cytokine production and Toll-like receptor-4 activation. Frontiers in Pharmacology 2016;7.7
(12) John Jeh Lung Tiong, Loo Jason, Chun Wai Mai. Global antimicrobial stewardship: A closer look at the formidable implementation challenges. Frontiers in Microbiology. 2016; 7:1860.
(11) Felicia Fei-Lei Chung, Chun Wai Mai, Pei Yuen Ng, Chee-Onn Leong. Roles of cytochrome P450 2W1 (CYP2W1) in colorectal cancers. Current Cancer Drug Targets. 2016;16(1):71-8
(10) John Jeh Lung Tiong, Chun Wai Mai, Pou Wee Gan, Vivienne Sook Li Mak, James Johnson. Separation of prescribing and dispensing in Malaysia: The history, necessities and challenges. International Journal of Pharmacy Practice. 2016 ;24(4):302-5
(9) John Jeh Lung Tiong, Chun Wai Mai, Audrey Yong. Academic integrity of healthcare educators – Requisite for nurturing professionalism. Medical Education. 2015(49):1060-1062
(8) Chun Wai Mai, Ramadas Anitha, John Jeh Lung Tiong, Pei Kuan Lai, Mallikarjuna Rao Pichika, Alexander Irvine Gray. Chemistry Content in the Pharmacy Curriculum: Relevance to Develop Pharmacists Fit-to-work in Diverse Pharmacy Profession Sectors. Indian Journal of Pharmaceutical Education and Research. 2015; 49(4):240-247
(7) Chun Wai Mai, Marzieh Yaeghoobi, Noorsaadah Abd-Rahman, Yew Beng Kang, Mallikarjuna Rao Pichika. Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins. European Journal of Medicinal Chemistry 2014: 77:378-87
(6) Polly Soo Xi Yap, Yik Tse Esther Chong, Yin Yau Wong, Xin Yee Lim, Jia Hui Ang, Heather Su Ling Goh, Mei Xuan Stephanie Lai, Chun Wai Mai, Ayuba Sunday Buru, Mallikarjuna Rao Pichika, Swee Hua Erin Lim. Antibacterial and antifungal testing of the different extracts of Dillenia obovata (Blume) Hoogl. World Journal of Pharmacy and Pharmaceutical Sciences. 2013; 2 (5): 3946-62
(5) Chun Wai Mai, Yew Beng Kang, Mallikarjuna Rao Pichika. Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: It’s expression and effects in ten most common cancers. OncoTargets and Therapy. 2013; 6:1573-87
(4) Boon Shing Tan, Owen Kang, Chun Wai Mai, Kai Hung Tiong, Alan Soo-Beng Khoo, Mallikarjuna Rao Pichika, Tracey D. Bradshaw and Chee-Onn Leong. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor-g (PPARg). Cancer Letters. 2013;336(1):127-139.
(3) Syed Shahzad Hasan, Pei Se Wong, Syed Imran Ahmed, David Weng Kwai Chong, Chun Wai Mai, Peter Pook, Therese Kairuz. Perceived Impact of Clinical Placements on Students Preparedness to Provide Patient-Centered Care in Malaysia. Currents in Pharmacy Teaching and Learning. 2013; 5(4): 303-10
(2) Chun Wai Mai, Wong Shin Yi, Tan Ee Ling, Katyayani Balijepalli Madhu Pichika Mallikarjuna Rao. Antiproliferative and Apoptotic Studies of the Standardised Extracts of Etlingera elatior on Human Colorectal Carcinoma Cells. Malaysian Journal of Chemistry 2009; 11(1): 136-42.
(1) Chun Wai Mai, Premalatha Pakirisamy, Tay Ee Fen, Bavahrni Subramaniam, Zulkifli Hj Shamsuddin, Mallikarjuna Rao Pichika. Nasopharyngeal Carcinoma Cell Proliferation and Apoptosis Induced by the Standardised Ethanolic Extracts of Mucuna bracteata. Malaysian Journal of Chemistry 2009; 11(1): 143-38
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- Breast Cancer: Basic and Clinical Research;
- Cancer Management and Research;
- Cell Proliferation;
- Critical Reviews in Food Science and Nutrition;
- Current Drug Targets;
- DNA and Cell Biology;
- European Journal of Inflammation;
- Frontiers in Immunology
- Frontiers in Oncology;
- Frontiers in Pharmacology;
- Immunology;
- Integrated Pharmacy Research and Practice;
- International Journal of Biological Science;
- Investigational New Drugs;
- Journal of Biochemical and Molecular Toxicology;
- Journal of Biological Active Product from Nature;
- Journal of Experimental and Clinical Cancer Research;
- Letters in Drug Design & Discovery
- Molecular Oncology;
- Natural Product Research;
- OncoTargets and Therapy;
- Phytotherapy Research;
- PLoS One
- Associate Editor, Gene
- Topic Editor, Frontiers in Immunology
- Topic Editor, Frontiers in Oncology
- Topic Editor, Frontiers in Pharmacology
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- Gerard Sambu Kulwa (Main Supervisor: Associate Professor Dr Ooi Ing Hong), Master of Science in Analytical and Pharmaceutical Chemistry Thesis Defence, International Medical University, Malaysia.
- Looi Chin King (Main Supervisor: Professor Dr Leong Chee Onn), Doctor of Philosophy (Medical and Health Sciences), Thesis Defence, International Medical University, Malaysia.
- Choy Yee Wa (Main Supervisor: Professor Dr Leong Chee Onn), PhD in Medical and Health Sciences Thesis Defence, International Medical University, Malaysia.
- Lamia Noushin Sadeque Chowdhury (Main Supervisor: Associate Professor Dr Pan Yan), Master of Philosophy, Thesis Defence, Nottingham University, Malaysia.
- Chan Hui Yin (Main Supervisor: Associate Professor Dr Felicia Chung), Master of Science in Life Sciences, Thesis Defence, Sunway University, Malaysia.
- Che Muhammad Farhan bin Che Abdullah (Main Supervisor: Dr Nikman Adli Nor Hashim), Master of Science (Biotechnology), Thesis Defence, University Malaya, Malaysia.
- Siew Wei Sheng (Main Supervisor: Dr Yap Wei Hsum), Doctor of Philosophy (Science), Thesis Proposal Defence, Taylor’s University, Malaysia.
