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Professor Dr Saad Tayyab
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Professor Dr Saad Tayyab

Professor

Academic Qualifications

PhD in Biochemistry
M. Phil. Biochemistry
MSc. Biochemistry
BSc. (Hon) Chemistry

Areas of Interest
Drug-protein interaction
Protein folding & denaturation
Protein/Enzyme stability, Protein Structure-function.
Professional Bodies Membership

Fellow – Royal Society of Chemistry (UK) (since Dec.21, 2017)

Fellow – Royal Society of Biology (UK) (since Jul. 01, 2019)

Member – American Chemical Society (since Jan. 2020)

Member – Asian Council of Science Editors (2023)

Life Member – Malaysian Society for Biochemistry & Molecular Biology

Member – New York Academy of Sciences (1994-1995)

Research

Current research project (PI/Co-PI)

Grants

Collaboration

Status

1.    ‘Understanding molecular interaction between anti-malarial drugs (Mefloquine and Sulfadoxine) and human serum albumin through spectroscopic and molecular docking methods’

Faculty Research Grant, University of Malaya (GPF011B-2018) (2018–2021)

Bioinformatics Division, Institut Sains Biologi, Universiti Malaya

Completed

2.    ‘Biophysical and computational approaches to unravel the molecular interaction mechanism of bromodeoxyuridine with human serum albumin’

FRG Project, University of Malaya (FG025–17AFR) (2017–2019)

Bioinformatics Division, Institut Sains Biologi, Universiti Malaya

Completed

3.    ‘Functional molecules for lifestyle diseases – Stability and interaction of functional molecules with target site’

HIR Project, Ministry of Higher Education, Govt. of Malaysia (F000002–21001) (2011–2016)

Faculty of Science & Faculty of Medicine, University of Malaya

Completed

4.    ‘Studies on protein aggregation: Towards understanding the molecular mechanism involved in neurodegenerative diseases’

UMRG Project, University of Malaya (RG275/14AFR) (2014–2016)

-

Completed

5.    ‘Novel colorimetric and fluorogenic nanobiosensors for telomerase activity detection’

FRGS Project, Ministry of Higher Education, Govt. of Malaysia (FRGS/2/2014/SG06/UNIM/02/1) (2015–2017)

Nottingham University, Malaysia campus

Completed

6.    ‘Conformational stability and activity of Champedak galactose binding lectin exposed to urinary variables and storage condition’

FRGS Project, Ministry of Higher Education, Govt. of Malaysia (FRGS/2/2013/ST04/UM/02/4) (2014–2016)

-

Completed

 

 

 

 

Supervision: 

Master students (Current) 

1. Ji Nigui (1002162722)

2. Haya Mohammed Qaid AlMansari (1002267240)

 

Undergraduate students (Current)

 Lau Yun Ying (1001954916)

 

Publications

  1. Abubakar, M., Mohamad, S.B., Halim, A.A.A. & Tayyab, S. (2023). Use of computational and wet lab techniques to examine the molecular association between a potent hepatitis C virus inhibitor, PSI-6206 and human serum albumin. Spectrochimica Acta-Part A: Molecular and Biomolecular Spectroscopy 294, 122543.
  2. Kandandapani, S., Kabir, M.Z., Tayyab, H, Mohamad, S.B. & Tayyab, S. (2022). Molecular recognition between anticancer drug, regorafenib and human serum albumin: Interaction revisited. Croatica Chemica Acta 95 (2), 57-68.
  3. Abubakar, M., Kandandapani, S., Mohamed, S.B., Halim, A.A.A. & Tayyab, S. (2022). Shedding light on the molecular interaction between the Hepatitis B virus inhibitor, clevudine, and human serum albumin: Thermodynamic, spectroscopic, microscopic, and in silico analyses. Journal of Molecular Liquids, 368, 120737.
  4. Kandandapani, S., Kabir, M.Z., Ridzwan, N.F.W., Mohamad, S.B. & Tayyab, S. (2022). Biomolecular interaction mechanism of an anticancer drug, pazopanib with human serum albumin: A multi-spectroscopic and computational approach. Journal of Biomolecular Structure and Dynamics, 40(18), 8312–8323.
  5. Kabir, M.Z., Mohamad, S.B., Omer, N., Choo, Y.-M. & Tayyab, S. (2022). Computational view of β-asarone-human serum albumin interaction. Biointerface Research in Applied Chemistry, 12(4), 5296–5302.
  6. Tayyab, S., Mat, T.N.N.T. & Halim, A.A.A. (2022). Differential stabilizing effects of buffers on structural stability of bovine serum albumin against urea denaturation. Latin American Applied Research, 52(1), 7-13.
  7. Halim, A.A.A., Ridzwan, F.W., Mohamad, S.B. & Tayyab, S. (2022). Targeting the nalidixic acid binding site on human serum albumin through computational approach: A re-investigation. Biointerface Research in Applied Chemistry, 12(2), 1520–1525.
  8. Tayyab, S. & Feroz, S.R. (2021). Serum albumin: Clinical significance of drug binding and development as drug delivery vehicle. Advances in Protein Chemistry and Structural Biology, 123, 193–218.
  9. Tayyab, S., Magesvaran, M.K.A., Kabir, M.Z., Ridzwan, N.F.W. & Mohamad, S.B. (2021). Biophysical and computational view on the in vitro combination between an anticancer drug, saracatinib and human serum albumin. Journal of Biomolecular Structure and Dynamics, 39(10), 3565–3575.
  10. Tan, C.Y., Lim, C.S., Liew, S.M., Halim, A.A.A. & Tayyab, S. (2021). Lysine modification of human serum albumin and its effect on protein conformation and nalidixic acid binding. Journal of the Indian Chemical Society, 98(3), 100031.

Journal Reviewers

  1. Journal of Molecular Liquids (Elsevier)
  2. Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy (Elsevier)
  3. Journal of Biomolecular Structure and Dynamics (Taylor & Francis)
  4. Scientific Reports (Nature Publishing Group)
  5. Frontiers in Pharmacology (Frontiers)
  6. PLoS ONE (Public Library of Science)
  7. RSC Advances (Royal Society of Chemistry)
  8. New Journal of Chemistry (Royal Society of Chemistry)
  9. Journal of Agricultural and Food Chemistry (American Chemical Society)
  10. Heliyon (Elsevier)
  11. Journal of Physical Chemistry (American Chemical Society)
  12. Biomacromolecules (American Chemical Society)
  13. Journal of Molecular Recognition (Wiley)
  14. Journal of Biochemical and Molecular Toxicology (Wiley)
  15. Luminescence: Journal of Biological and Chemical Luminescence (Wiley) International Journal of Biological Macromolecules (Elsevier)
  16.  Journal of Photochemistry and Photobiology B: Biology (Elsevier)
  17. Journal of Luminescence (Elsevier)
  18. Colloids and Surfaces B: Biointerfaces (Elsevier)
  19. Chemosphere (Elsevier)
  20. LWT - Food Science & Technology (Elsevier)
  21. Food Chemistry (Elsevier)
  22. Science of the Total Environment (Elsevier)
  23. Journal of Pharmaceutical and Biomedical Analysis (Elsevier)
  24. Biochimie (Elsevier)
  25. Journal of Molecular Structure (Elsevier)
  26. Pesticide Biochemistry and Physiology (Elsevier)
  27. Food Hydrocolloids (Elsevier)
  28. Journal of Molecular Catalysis B: Enzymatic (Elsevier)
  29. Journal of Industrial and Engineering Chemistry (Elsevier)
  30. Analytical Chemistry Letters (Taylor & Francis)
  31. Spectroscopy Letters (Taylor & Francis)
  32. Journal of Environmental Science & Health Part B (Taylor & Francis)
  33. Molecular Biology Reports (Springer)
  34. European Biophysics Journal (Springer)
  35. Bioprocess & Biosystems Engineering (Springer)
  36. Applied Biochemistry and Biotechnology (Springer)
  37. International Journal of Peptide Research & Therapeutics (Springer);
  38. IET Nanobiotechnology (Institution of Engineering & Technology)
  39. Micro & Nano Letters (Institution of Engineering & Technology)
  40. Canadian Journal of Physiology & Pharmacology (Canadian Science Publishing)
  41. Acta Chimica Slovenica (Slovensko Kemijsko Drustvo)
  42. General Physiology and Biophysics (Slovak Academy of Sciences)

Editorial Board Member

  1. Chief Editor – Malaysian Journal of Biochemistry & Molecular Biology (2015–2017)
  2. Frontiers in Molecular Biosciences (since 2022) (Frontiers Journals)
  3. Letters in Drug Design & Discovery (since 2015) (Bentham Science)
  4. Protein and Peptide Letters (since 2019) (Bentham Science)
  5. Biochemistry Research International (since 2013) (Hindawi)
  6. Biomedical Reports (2023) (Spandidos Publications)
  7. Vegetos (2019-2021) (Springer)
  8. Bioscience Education e-Journal (2008–2011) (Higher Education Academy, UK)
  9. Indian Journal of Clinical Biochemistry (2002–2004) (Springer) 

Awards and Recognitions

  • Certificate of Excellence Award for Outstanding Faculty of the Year (2023) – at the 8th South Asian Education Award & Summit 2023. EET CRS, Research Wing for Excellence in Professional Education & Industry, Education Expo TV, India.

 

  • Honorary Fellow – Institute for Engineering Research & Publication (IFERP), India (2019)

 

  • Bentham Ambassador – (2018–2019) Bentham Science, UAE

 

  • Lifetime Achievement Award (Aug. 11, 2018) – Venus International Foundation, India•

 

  • Certificate of Excellence (Research Category) – (Mar. 18, 2018) EET CRS, Research Wing for Excellence in Professional Education & Industry, Education Expo TV, India.

 

  • 10th Anniversary Collection focusing on Molecular Modelling ‘RSC Advances’ (2021) includes one of our Articles entitled ‘Interaction of An Anticancer Drug, Gefitinib With Human Serum Albumin: Insights from Fluorescence Spectroscopy and Computational Modeling Analysis’. RSC Advances (2016) 6, 91756–91767 (RSC Publishing).

 

  • Journal Cover Page ‘Advances in Protein Chemistry and Structural Biology’ (2021) represents a Diagram from our Research Article ‘Serum Albumin: Clinical Significance of Drug Binding and Development as Drug Delivery Vehicle’. Advances in Protein Chemistry and Structural Biology (2021) 123, 193-218 (Elsevier).

 

  • Journal Cover Page ‘Biopolymers’ (2020) represents a Diagram from our Research Article ‘Combination Mode of Antimalarial Drug Mefloquine and Human Serum Albumin: Insights from Spectroscopic and Docking Approaches’. Biopolymers (2020) 111, e23337 (Wiley).

 

  • Expert # 1 in Fluorescence Spectrometry in Malaysia according to Expertscape (2020).

 

Other achievements

 

  • Referee – Academic Promotion (2022) to evaluate the research work of the lecturer in the Faculty of Pharmacy, Middle East University, Jordan, for promotion to the rank of Professor.

 

  • Referee – Academic Promotion (2022) to evaluate the research work of the lecturer in the Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia, for promotion to the rank of Professor.

 

  • Referee – Academic Promotion (2020) to evaluate the research work of the lecturer in the Department of Life Sciences, King Saud University, Kingdom of Saudi Arabia, for promotion to the rank of Associate Professor.

 

  • Referee – Academic Promotion (2016) to evaluate the research work of the lecturer in the Department of Physiology & Biochemistry, Faculty of Medicine, University of Jordan, Jordan, for promotion to the rank of Associate Professor.

 

  • Referee – Academic Promotion (2019) to evaluate the candidature of the lecturer  in the Institute of Biological Sciences, Universiti Malaya, for promotion to the rank of Associate Professor.

 

  • Referee – Academic Promotion (2018) to evaluate the candidature of the lecturer in the Institute of Biological Sciences, Universiti Malaya, for promotion to the rank of Professor.

 

  • Referee – Academic Promotion (2018) to evaluate the candidature of the lecturer in the Institute of Biological Sciences, Universiti Malaya, for promotion to the rank of Associate Professor.

 

  • Examiner (Internal) – Ph.D. Thesis (2022) ‘Pharmacokinetic interactions effect of standardized Vernonia amygdalina on metformin in oral fixed-dose combination therapy and its modulatory effect on hepatic microsomal enzymes in diabetic sprague-dawley rats’ (Bassel Al Sabbagh) UCSI University.

 

  • Examiner (External) – Ph.D. Thesis (2021) ‘Quality-by-design approach for development and validation of UPLC and HPLC methods to quantify the pharmaceutically important molecules’ (Nukendra Prasad Nadella) Vignan’s Foundation for Science, Technology & Research (Deemed to be University), India.

 

  • Examiner (External) – Ph.D. Thesis (2021) ‘Immunochemical studies on methylglyoxal modified plasma fibrinogen' (Shahida Perween) Aligarh Muslim University, India.

 

  • Examiner (External) – Ph.D. Thesis (2020) ‘Phytochemical investigation and evaluation of antioxidant, antibacterial and anticancer potential of Trichopus zeylanicus and Samadera indica from South India’ (C. Sindhu) Bharathiar University, India.

 

  • Examiner (External) – Ph.D. Thesis (2020) ‘Altered recognition by the protein degradation machinery re-programmes proteostasis in cancer cells’ (Alaa Mamdouh Abdallah) Cairo University, Egypt.

 

  • Examiner (External) – Ph.D. Thesis (2019) ‘Green synthesis of nanoparticles and assessment of their anti-bacterial, anti-fungal and anti-proliferative activities’ (Khursheed Ali) Aligarh Muslim University, India.

 

  • Examiner (External) – Ph.D. Thesis (2019) ‘Role of pro-inflammatory cytokines in the pathogenesis of rheumatoid arthritis’ (Somaiya Mateen) Aligarh Muslim University, India.

 

  • Examiner (External) – Ph.D. Thesis (2019) ‘Synthesis of some novel hybrid molecules and evaluation of their in vitro cytotoxic activities’ (Arunkumar Thirivedhi) Vignan’s Foundation for Science, Technology & Research (Deemed to be University), India.

 

External international grant reviewer

2017. International Grant Reviewer. Chilean National Science and Technology Commission (CONICYT - Chile).

 

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